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Plch2 phospholipase C eta 2 [ Cricetulus griseus (Chinese hamster) ]

Gene ID: 100769053, updated on 26-Mar-2025
Gene symbol
Plch2
Gene description
phospholipase C eta 2
Locus tag
I79_022921
See related
Ensembl:ENSCGRG00015013479
Gene type
protein coding
RefSeq status
MODEL
Organism
Cricetulus griseus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Cricetinae; Cricetulus
Orthologs
human mouse all
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Location:
chromosome: 2
Exon count:
22
Annotation release Status Assembly Chr Location
104 current CriGri_1.0 (GCF_000223135.1) Unplaced Scaffold NW_003616165.1 (77576..148036, complement)
104 current CriGri-PICRH-1.0 (GCF_003668045.3) 2 NC_048595.1 (1264152..1334473)

NW_003616165.1Genomic Context describing neighboring genes Neighboring gene TNF receptor superfamily member 14 Neighboring gene pantothenate kinase 4 (inactive)

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol-4,5-bisphosphate phospholipase C activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2
Names
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase eta-2

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RefSeqs of Annotated Genomes: Cricetulus griseus Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference CriGri_1.0 Primary Assembly

Genomic

  1. NW_003616165.1 Reference CriGri_1.0 Primary Assembly

    Range
    77576..148036 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_007654048.4 → XP_007652238.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2

    UniProtKB/TrEMBL
    A0A8C2M697
    Conserved Domains (7) summary
    cd00275
    Location:760 → 885
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08633
    Location:321 → 730
    PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
    PLN02952
    Location:238 → 870
    PLN02952; phosphoinositide phospholipase C
    cd00051
    Location:169 → 235
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd13364
    Location:45 → 151
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    pfam09279
    Location:239 → 321
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:170 → 231
    EF-hand_7; EF-hand domain pair

Alternate CriGri-PICRH-1.0

Genomic

  1. NC_048595.1 Alternate CriGri-PICRH-1.0

    Range
    1264152..1334473
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_035439344.1 → XP_035295235.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2

    UniProtKB/TrEMBL
    A0A8C2M697, A0A9J7K4F7
    Related
    ENSCGRP00015018228.1, ENSCGRT00015022393.2
    Conserved Domains (5) summary
    cd08633
    Location:321 → 730
    PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
    PLN02228
    Location:243 → 870
    PLN02228; Phosphoinositide phospholipase C
    PHA03247
    Location:919 → 1243
    PHA03247; large tegument protein UL36; Provisional
    cd13364
    Location:45 → 151
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd16221
    Location:169 → 309
    EFh_PI-PLCeta2; EF-hand motif found in phosphoinositide phospholipase C eta 2 (PI-PLC-eta2)
Nucleotide Protein Strain
Heading Accession and Version

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