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Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 [ Cricetulus griseus (Chinese hamster) ]

Gene ID: 100763862, updated on 8-Mar-2024

Summary

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Gene symbol
Mthfd1
Gene description
methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
See related
Ensembl:ENSCGRG00015027761
Gene type
protein coding
RefSeq status
MODEL
Organism
Cricetulus griseus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Cricetinae; Cricetulus
Orthologs
human mouse all
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Genomic context

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See Mthfd1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
28
Annotation release Status Assembly Chr Location
104 current CriGri_1.0 (GCF_000223135.1) Unplaced Scaffold NW_003613728.1 (2052238..2119931)
104 current CriGri-PICRH-1.0 (GCF_003668045.3) 5 NC_048598.1 (127173702..127241378, complement)

NW_003613728.1Genomic Context describing neighboring genes Neighboring gene spectrin repeat containing nuclear envelope protein 2 Neighboring gene estrogen receptor 2 Neighboring gene coiled-coil domain-containing protein 170-like Neighboring gene A-kinase anchoring protein 5 Neighboring gene zinc finger and BTB domain containing 25

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing. Becker J, et al. J Biotechnol, 2011 Dec 10. PMID 21945585
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables formate-tetrahydrofolate ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables methenyltetrahydrofolate cyclohydrolase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables methylenetetrahydrofolate dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in tetrahydrofolate interconversion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
C-1-tetrahydrofolate synthase, cytoplasmic
Names
c-1-tetrahydrofolate synthase, cytoplasmic-like protein
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Cricetulus griseus Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference CriGri_1.0 Primary Assembly

Genomic

  1. NW_003613728.1 Reference CriGri_1.0 Primary Assembly

    Range
    2052238..2119931
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003499309.4 → XP_003499357.1  C-1-tetrahydrofolate synthase, cytoplasmic

    See identical proteins and their annotated locations for XP_003499357.1

    UniProtKB/TrEMBL
    A0A8C2QHC3, G3H4Z5
    Conserved Domains (4) summary
    cd01080
    Location:120 → 292
    NAD_bind_m-THF_DH_Cyclohyd; NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
    PLN02759
    Location:309 → 936
    PLN02759; Formate--tetrahydrofolate ligase
    COG0190
    Location:6 → 297
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    pfam00763
    Location:6 → 125
    THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain

Alternate CriGri-PICRH-1.0

Genomic

  1. NC_048598.1 Alternate CriGri-PICRH-1.0

    Range
    127173702..127241378 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_027418284.2 → XP_027274085.1  C-1-tetrahydrofolate synthase, cytoplasmic

    UniProtKB/TrEMBL
    A0A8C2QHC3, G3H4Z5
    Related
    ENSCGRP00015037023.1, ENSCGRT00015045166.2
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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