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Acacb acetyl-Coenzyme A carboxylase beta [ Mus musculus (house mouse) ]

Gene ID: 100705, updated on 5-Feb-2023

Summary

Official Symbol
Acacbprovided by MGI
Official Full Name
acetyl-Coenzyme A carboxylase betaprovided by MGI
Primary source
MGI:MGI:2140940
See related
Ensembl:ENSMUSG00000042010 AllianceGenome:MGI:2140940
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Acc2; Accb
Summary
Enables acetyl-CoA carboxylase activity. Involved in several processes, including energy homeostasis; malonyl-CoA biosynthetic process; and negative regulation of fatty acid beta-oxidation. Acts upstream of or within fatty acid biosynthetic process. Located in mitochondrion. Is expressed in axial skeleton; cranium; and liver. Orthologous to human ACACB (acetyl-CoA carboxylase beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in mammary gland adult (RPKM 37.5), heart adult (RPKM 32.1) and 13 other tissues See more
Orthologs
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Genomic context

See Acacb in Genome Data Viewer
Location:
5; 5 F
Exon count:
56
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (114284378..114388822)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (114146321..114250761)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 30 Neighboring gene legumain pseudogene Neighboring gene alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase Neighboring gene uracil DNA glycosylase Neighboring gene forkhead box N4 Neighboring gene VISTA enhancer mm1522 Neighboring gene myosin 1H

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables acetyl-CoA carboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables acetyl-CoA carboxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables acetyl-CoA carboxylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables acetyl-CoA carboxylase activity ISO
Inferred from Sequence Orthology
more info
 
enables biotin binding ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in acetyl-CoA metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in energy homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in malonyl-CoA biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of catalytic activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of fatty acid beta-oxidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of fatty acid oxidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of lipid catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of heart growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of lipid storage IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein homotetramerization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to nutrient levels IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
acetyl-CoA carboxylase 2
Names
ACC-beta
NP_598665.2
XP_006530174.1
XP_006530175.1
XP_006530176.1
XP_006530177.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403527.1NP_001390456.1  acetyl-CoA carboxylase 2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC122282
  2. NM_001403528.1NP_001390457.1  acetyl-CoA carboxylase 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122282
  3. NM_001403529.1NP_001390458.1  acetyl-CoA carboxylase 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC122282
  4. NM_133904.3NP_598665.2  acetyl-CoA carboxylase 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_598665.2

    Status: VALIDATED

    Source sequence(s)
    AC122282
    Consensus CDS
    CCDS19561.1
    UniProtKB/Swiss-Prot
    E9Q4Z2, Q6JIZ0
    UniProtKB/TrEMBL
    Q3UHC8, Q9ESZ3
    Related
    ENSMUSP00000031583.9, ENSMUST00000031583.15
    Conserved Domains (4) summary
    COG0439
    Location:250753
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00364
    Location:887951
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:17702324
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:9521678
    ACC_central; Acetyl-CoA carboxylase, central region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    114284378..114388822
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530111.4XP_006530174.1  acetyl-CoA carboxylase 2 isoform X1

    Conserved Domains (4) summary
    COG0439
    Location:250753
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00364
    Location:887951
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:17912345
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:9521699
    ACC_central; Acetyl-CoA carboxylase, central region
  2. XM_006530113.4XP_006530176.1  acetyl-CoA carboxylase 2 isoform X2

    UniProtKB/Swiss-Prot
    E9Q4Z2
    Related
    ENSMUSP00000099642.2, ENSMUST00000102582.8
    Conserved Domains (4) summary
    COG0439
    Location:250753
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00364
    Location:887951
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:17702324
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:9521678
    ACC_central; Acetyl-CoA carboxylase, central region
  3. XM_006530112.4XP_006530175.1  acetyl-CoA carboxylase 2 isoform X1

    See identical proteins and their annotated locations for XP_006530175.1

    Conserved Domains (4) summary
    COG0439
    Location:250753
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00364
    Location:887951
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:17912345
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:9521699
    ACC_central; Acetyl-CoA carboxylase, central region
  4. XM_006530114.5XP_006530177.1  acetyl-CoA carboxylase 2 isoform X3

    Conserved Domains (4) summary
    COG0439
    Location:58561
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00364
    Location:695759
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:15992153
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:7601507
    ACC_central; Acetyl-CoA carboxylase, central region