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RWDD2B RWD domain containing 2B [ Homo sapiens (human) ]

Gene ID: 10069, updated on 7-Jun-2020

Summary

Official Symbol
RWDD2Bprovided by HGNC
Official Full Name
RWD domain containing 2Bprovided by HGNC
Primary source
HGNC:HGNC:1302
See related
Ensembl:ENSG00000156253 MIM:617843
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GL011; C21orf6
Expression
Ubiquitous expression in testis (RPKM 9.4), prostate (RPKM 8.5) and 25 other tissues See more
Orthologs

Genomic context

See RWDD2B in Genome Data Viewer
Location:
21q21.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (29004384..29019371, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (30378080..30391685, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372766 Neighboring gene ribosomal protein L23 pseudogene 2 Neighboring gene ubiquitin specific peptidase 16 Neighboring gene chaperonin containing TCP1 subunit 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
RWD domain-containing protein 2B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320724.1NP_001307653.1  RWD domain-containing protein 2B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' coding region that results in use of a downstream start AUG compared to variant 1. It encodes isoform 2, which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AA406228, AF129075, BI710995, CA425694, DB039085
    Related
    ENST00000486719.5
    Conserved Domains (2) summary
    pfam05773
    Location:5133
    RWD; RWD domain
    pfam06544
    Location:163222
    DUF1115; Protein of unknown function (DUF1115)
  2. NM_016940.3NP_058636.1  RWD domain-containing protein 2B isoform 1

    See identical proteins and their annotated locations for NP_058636.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AF129075, AL355727, BC012546, BC017912
    Consensus CDS
    CCDS13582.1
    UniProtKB/Swiss-Prot
    P57060
    Related
    ENSP00000418693.1, ENST00000493196.2
    Conserved Domains (2) summary
    pfam05773
    Location:37162
    RWD; RWD domain
    pfam06544
    Location:192310
    DUF1115; Protein of unknown function (DUF1115)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    29004384..29019371 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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