U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SP110 SP110 nuclear body protein [ Canis lupus familiaris (dog) ]

Gene ID: 100686387, updated on 25-Jul-2026
Official Symbol
SP110provided by VGNC
Official Full Name
SP110 nuclear body proteinprovided by VGNC
Primary source
VGNC:VGNC:46685
See related
Ensembl:ENSCAFG00845020232 RGD:12174811
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See SP110 in Genome Data Viewer
Location:
chromosome: 25
Exon count:
22
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 25 NC_051829.1 (42674227..42715740, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 25 NC_006607.4 (43043085..43084557, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 25 NC_049246.1 (42601276..42643009, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 25 NC_049285.1 (42604301..42645746, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 25 NC_049766.1 (42445973..42487547, complement)

Chromosome 25 - NC_051829.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 16 member 14 Neighboring gene probable G-protein coupled receptor 148 Neighboring gene uncharacterized LOC119865959 Neighboring gene uncharacterized LOC111092284 Neighboring gene SP140 nuclear body protein

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Variants within the SP110 nuclear body protein modify risk of canine degenerative myelopathy. Ivansson EL, et al. Proc Natl Acad Sci U S A, 2016 May 31. PMID 27185954, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Homozygous superoxide dismutase 1 gene mutation is associated with degenerative myelopathy.
    Title: Variants within the SP110 nuclear body protein modify risk of canine degenerative myelopathy.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
sp110 nuclear body protein

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051829.1 Reference ROS_Cfam_1.0

    Range
    42674227..42715740 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038435713.1 → XP_038291641.1  sp110 nuclear body protein isoform X2

    UniProtKB/TrEMBL
    A0A0U2KQ38, A0A8I3PCP3
    Related
    ENSCAFP00845027921.1, ENSCAFT00845035687.1
    Conserved Domains (5) summary
    cd05501
    Location:594 → 694
    Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
    cd15626
    Location:530 → 571
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:453 → 524
    SAND; SAND domain
    pfam03172
    Location:15 → 113
    HSR; HSR domain
    NF033483
    Location:182 → 247
    PknB_PASTA_kin; Stk1 family PASTA domain-containing Ser/Thr kinase

  2. XM_038435714.1 → XP_038291642.1  sp110 nuclear body protein isoform X3

    UniProtKB/TrEMBL
    A0A0U2KUF8, E2R0A1
    Conserved Domains (4) summary
    cd05501
    Location:593 → 693
    Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
    cd15626
    Location:529 → 570
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:437 → 512
    SAND; SAND domain
    pfam03172
    Location:15 → 113
    HSR; HSR domain

  3. XM_038435716.1 → XP_038291644.1  sp110 nuclear body protein isoform X5

    UniProtKB/TrEMBL
    A0A0U2JXS9
    Conserved Domains (5) summary
    cd05501
    Location:577 → 677
    Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
    cd15626
    Location:513 → 554
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:436 → 507
    SAND; SAND domain
    pfam03172
    Location:15 → 113
    HSR; HSR domain
    NF033483
    Location:182 → 247
    PknB_PASTA_kin; Stk1 family PASTA domain-containing Ser/Thr kinase

  4. XM_038435715.1 → XP_038291643.1  sp110 nuclear body protein isoform X4

    UniProtKB/TrEMBL
    A0A0U2KTF7
    Related
    ENSCAFP00845028056.1, ENSCAFT00845035858.1
    Conserved Domains (5) summary
    cd05501
    Location:592 → 692
    Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
    cd15626
    Location:528 → 569
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:436 → 511
    SAND; SAND domain
    pfam03172
    Location:15 → 113
    HSR; HSR domain
    NF033483
    Location:182 → 247
    PknB_PASTA_kin; Stk1 family PASTA domain-containing Ser/Thr kinase

  5. XM_038435712.1 → XP_038291640.1  sp110 nuclear body protein isoform X1

    UniProtKB/TrEMBL
    A0A0U2KUF8, A0A8I3PD85, E2R0A1
    Related
    ENSCAFP00845028137.1, ENSCAFT00845035953.1
    Conserved Domains (5) summary
    cd05501
    Location:609 → 709
    Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
    cd15626
    Location:545 → 586
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:453 → 528
    SAND; SAND domain
    pfam03172
    Location:15 → 113
    HSR; HSR domain
    NF033483
    Location:182 → 247
    PknB_PASTA_kin; Stk1 family PASTA domain-containing Ser/Thr kinase

  6. XM_038435717.1 → XP_038291645.1  sp110 nuclear body protein isoform X6

    Conserved Domains (3) summary
    pfam01342
    Location:453 → 528
    SAND; SAND domain
    pfam03172
    Location:15 → 113
    HSR; HSR domain
    NF033483
    Location:182 → 247
    PknB_PASTA_kin; Stk1 family PASTA domain-containing Ser/Thr kinase

  7. XM_038435718.1 → XP_038291646.1  sp110 nuclear body protein isoform X7

    Conserved Domains (3) summary
    pfam01342
    Location:453 → 528
    SAND; SAND domain
    pfam03172
    Location:15 → 113
    HSR; HSR domain
    NF033483
    Location:182 → 247
    PknB_PASTA_kin; Stk1 family PASTA domain-containing Ser/Thr kinase

RNA

  1. XR_005301932.1 RNA Sequence

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049285.1 Alternate UMICH_Zoey_3.1

    Range
    42604301..42645746 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038510645.1 → XP_038366573.1  

  2. XM_038510646.1 → XP_038366574.1  

  3. XM_038510648.1 → XP_038366576.1  

  4. XM_038510647.1 → XP_038366575.1  

  5. XM_038510644.1 → XP_038366572.1  

  6. XM_038510649.1 → XP_038366577.1  

  7. XM_038510650.1 → XP_038366578.1  

RNA

  1. XR_005344919.1 RNA Sequence

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049766.1 Alternate UNSW_CanFamBas_1.0

    Range
    42445973..42487547 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038638432.1 → XP_038494360.1  

  2. XM_038638433.1 → XP_038494361.1  

  3. XM_038638435.1 → XP_038494363.1  

  4. XM_038638434.1 → XP_038494362.1  

  5. XM_038638431.1 → XP_038494359.1  

  6. XM_038638436.1 → XP_038494364.1  

  7. XM_038638437.1 → XP_038494365.1  

RNA

  1. XR_005412609.1 RNA Sequence

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049246.1 Alternate UU_Cfam_GSD_1.0

    Range
    42601276..42643009 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038574131.1 → XP_038430059.1  sp110 nuclear body protein isoform X3

    UniProtKB/TrEMBL
    A0A0U2KUF8, E2R0A1

  2. XM_038574130.1 → XP_038430058.1  sp110 nuclear body protein isoform X2

    UniProtKB/TrEMBL
    A0A0U2KQ38

  3. XM_038574133.1 → XP_038430061.1  sp110 nuclear body protein isoform X5

    UniProtKB/TrEMBL
    A0A0U2JXS9

  4. XM_038574132.1 → XP_038430060.1  sp110 nuclear body protein isoform X4

    UniProtKB/TrEMBL
    A0A0U2KTF7

  5. XM_038574129.1 → XP_038430057.1  sp110 nuclear body protein isoform X1

    UniProtKB/TrEMBL
    A0A0U2KUF8, E2R0A1

  6. XM_038574134.1 → XP_038430062.1  sp110 nuclear body protein isoform X6

  7. XM_038574135.1 → XP_038430063.1  sp110 nuclear body protein isoform X7

RNA

  1. XR_005378781.1 RNA Sequence

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006607.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    43043085..43084557 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_014107514.3 → XP_013962989.2  sp110 nuclear body protein isoform X3

    UniProtKB/TrEMBL
    A0A0U2KUF8, E2R0A1
    Conserved Domains (4) summary
    cd05501
    Location:593 → 693
    Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
    cd15626
    Location:529 → 570
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:437 → 512
    SAND; SAND domain
    pfam03172
    Location:15 → 113
    HSR; HSR domain

  2. XM_022409643.2 → XP_022265351.2  sp110 nuclear body protein isoform X2

    UniProtKB/TrEMBL
    A0A0U2KQ38
    Conserved Domains (6) summary
    cd05501
    Location:594 → 694
    Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
    PHA03307
    Location:159 → 377
    PHA03307; transcriptional regulator ICP4; Provisional
    cd15626
    Location:530 → 571
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:453 → 524
    SAND; SAND domain
    pfam03172
    Location:15 → 113
    HSR; HSR domain
    NF033483
    Location:182 → 247
    PknB_PASTA_kin; Stk1 family PASTA domain-containing Ser/Thr kinase

  3. XM_022409645.2 → XP_022265353.2  sp110 nuclear body protein isoform X5

    UniProtKB/TrEMBL
    A0A0U2JXS9
    Conserved Domains (5) summary
    cd05501
    Location:577 → 677
    Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
    cd15626
    Location:513 → 554
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:436 → 507
    SAND; SAND domain
    pfam03172
    Location:15 → 113
    HSR; HSR domain
    NF033483
    Location:182 → 247
    PknB_PASTA_kin; Stk1 family PASTA domain-containing Ser/Thr kinase

  4. XM_022409644.2 → XP_022265352.2  sp110 nuclear body protein isoform X4

    UniProtKB/TrEMBL
    A0A0U2KTF7
    Conserved Domains (5) summary
    cd05501
    Location:592 → 692
    Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
    cd15626
    Location:528 → 569
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:436 → 511
    SAND; SAND domain
    pfam03172
    Location:15 → 113
    HSR; HSR domain
    NF033483
    Location:182 → 247
    PknB_PASTA_kin; Stk1 family PASTA domain-containing Ser/Thr kinase

  5. XM_005635823.4 → XP_005635880.2  sp110 nuclear body protein isoform X1

    UniProtKB/TrEMBL
    A0A0U2KUF8, E2R0A1
    Conserved Domains (6) summary
    cd05501
    Location:609 → 709
    Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
    PHA03307
    Location:159 → 377
    PHA03307; transcriptional regulator ICP4; Provisional
    cd15626
    Location:545 → 586
    PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
    pfam01342
    Location:453 → 528
    SAND; SAND domain
    pfam03172
    Location:15 → 113
    HSR; HSR domain
    NF033483
    Location:182 → 247
    PknB_PASTA_kin; Stk1 family PASTA domain-containing Ser/Thr kinase

  6. XM_022409646.2 → XP_022265354.2  sp110 nuclear body protein isoform X6

    Conserved Domains (3) summary
    pfam01342
    Location:453 → 528
    SAND; SAND domain
    pfam03172
    Location:15 → 113
    HSR; HSR domain
    NF033483
    Location:182 → 247
    PknB_PASTA_kin; Stk1 family PASTA domain-containing Ser/Thr kinase

  7. XM_038458456.1 → XP_038314384.1  sp110 nuclear body protein isoform X7

    Conserved Domains (3) summary
    pfam01342
    Location:453 → 528
    SAND; SAND domain
    pfam03172
    Location:15 → 113
    HSR; HSR domain
    NF033483
    Location:182 → 247
    PknB_PASTA_kin; Stk1 family PASTA domain-containing Ser/Thr kinase

RNA

  1. XR_002618980.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials