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CLDN5 claudin 5 [ Canis lupus familiaris (dog) ]

Gene ID: 100684266, updated on 8-Mar-2024

Summary

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Official Symbol
CLDN5provided by VGNC
Official Full Name
claudin 5provided by VGNC
Primary source
VGNC:VGNC:111411
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 26
Exon count:
1
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 26 NC_051830.1 (31103894..31106387)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 26 NC_006608.4 (29657506..29659994)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 26 NC_049247.1 (29862380..29864535)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 26 NC_049286.1 (29151222..29153712)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 26 NC_049767.1 (28776939..28779430)

Chromosome 26 - NC_051830.1Genomic Context describing neighboring genes Neighboring gene T-box transcription factor 1 Neighboring gene septin 5 Neighboring gene cell division cycle 45 Neighboring gene ubiquitin recognition factor in ER associated degradation 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression of claudin-5 in canine pancreatic acinar cell carcinoma - An immunohistochemical study. Jakab C, et al. Acta Vet Hung, 2011 Mar. PMID 21354944
  2. Expression of claudin-5 in hepatoid gland biopsies. Jakab C, et al. Vet Dermatol, 2010 Jun. PMID 20136787
  3. Evaluation of microvessel density (MVD) in canine mammary tumours by quantitative immunohistochemistry of the claudin-5 molecule. Jakab C, et al. Acta Vet Hung, 2008 Dec. PMID 19149104

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. strong expression in normal hepatoid glands, nodular hyperplasia, adenomas and well-differentiated carcinomas, with lower expression in epitheliomas and increased expression in anaplastic, poorly differentiated carcinomas
    Title: Expression of claudin-5 in hepatoid gland biopsies.
  2. It seems that the loss of expression of claudin-5 may lead to carcinogenesis in canine exocrine pancreatic cells.
    Title: Expression of claudin-5 in canine pancreatic acinar cell carcinoma - An immunohistochemical study.
  3. The relationship between microvessel density, caludin 5 metabolism, and neoplasm grade in canine mammary neoplasms is reported.
    Title: Evaluation of microvessel density (MVD) in canine mammary tumours by quantitative immunohistochemistry of the claudin-5 molecule.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in bicellular tight junction assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
claudin-5
Names
claudin 5 (transmembrane protein deleted in velocardiofacial syndrome)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051830.1 Reference ROS_Cfam_1.0

    Range
    31103894..31106387
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038436147.1 → XP_038292075.1  claudin-5

    Conserved Domains (1) summary
    cl21598
    Location:71 → 246
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049286.1 Alternate UMICH_Zoey_3.1

    Range
    29151222..29153712
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038512622.1 → XP_038368550.1  claudin-5

    Conserved Domains (1) summary
    cl21598
    Location:71 → 246
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049767.1 Alternate UNSW_CanFamBas_1.0

    Range
    28776939..28779430
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038638746.1 → XP_038494674.1  claudin-5

    Conserved Domains (1) summary
    cl21598
    Location:71 → 246
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049247.1 Alternate UU_Cfam_GSD_1.0

    Range
    29862380..29864535
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038574533.1 → XP_038430461.1  claudin-5

    Conserved Domains (1) summary
    cl21598
    Location:71 → 246
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006608.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    29657506..29659994
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005636589.4 → XP_005636646.1  claudin-5

    Conserved Domains (1) summary
    cl21598
    Location:71 → 246
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
Nucleotide Protein
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