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Trrap transformation/transcription domain-associated protein [ Mus musculus (house mouse) ]

Gene ID: 100683, updated on 8-Dec-2022

Summary

Official Symbol
Trrapprovided by MGI
Official Full Name
transformation/transcription domain-associated proteinprovided by MGI
Primary source
MGI:MGI:2153272
See related
Ensembl:ENSMUSG00000045482 AllianceGenome:MGI:2153272
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables transcription coactivator activity. Acts upstream of or within regulation of transcription, DNA-templated. Part of transcription regulator complex. Is expressed in several structures, including cranial ganglion; submandibular gland primordium; testis; tooth; and vibrissa. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 75. Orthologous to human TRRAP (transformation/transcription domain associated protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 24.1), thymus adult (RPKM 17.5) and 28 other tissues See more
Orthologs
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Genomic context

See Trrap in Genome Data Viewer
Location:
5; 5 G2
Exon count:
75
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (144704547..144796588)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (144767737..144859778)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 130 Neighboring gene predicted gene, 38739 Neighboring gene predicted gene, 23995 Neighboring gene SMAD specific E3 ubiquitin protein ligase 1 Neighboring gene microRNA 7039 Neighboring gene predicted gene, 33821

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coregulator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in histone H2A acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in histone H3 acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in histone H3 acetylation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in histone H4 acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in histone acetylation NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within mitotic cell cycle checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in monoubiquitinated histone H2A deubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in monoubiquitinated histone deubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA repair NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of RNA splicing NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of double-strand break repair NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
part_of NuA4 histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
 
part_of SAGA complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of SAGA complex ISO
Inferred from Sequence Orthology
more info
 
part_of SAGA complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of Swr1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of histone acetyltransferase complex TAS
Traceable Author Statement
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription factor TFTC complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription factor TFTC complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transformation/transcription domain-associated protein
Names
tra1 homolog
transactivation/transformation-domain associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081362.2NP_001074831.1  transformation/transcription domain-associated protein

    Status: VALIDATED

    Source sequence(s)
    AC113295, AC131728
    Consensus CDS
    CCDS39379.1
    UniProtKB/TrEMBL
    E9QLK7
    Related
    ENSMUSP00000098035.4, ENSMUST00000100467.10
    Conserved Domains (3) summary
    COG5032
    Location:25263847
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:34843771
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:28423174
    FAT; FAT domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    144704547..144796588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504782.3XP_006504845.1  transformation/transcription domain-associated protein isoform X1

    See identical proteins and their annotated locations for XP_006504845.1

    Conserved Domains (3) summary
    COG5032
    Location:25523911
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:35223835
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:28683211
    FAT; FAT domain
  2. XM_030254015.1XP_030109875.1  transformation/transcription domain-associated protein isoform X3

    Conserved Domains (3) summary
    COG5032
    Location:25513910
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:35213834
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:28673210
    FAT; FAT domain
  3. XM_006504781.3XP_006504844.1  transformation/transcription domain-associated protein isoform X1

    See identical proteins and their annotated locations for XP_006504844.1

    Conserved Domains (3) summary
    COG5032
    Location:25523911
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:35223835
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:28683211
    FAT; FAT domain
  4. XM_006504789.3XP_006504852.1  transformation/transcription domain-associated protein isoform X10

    Conserved Domains (3) summary
    COG5032
    Location:25523885
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:35223809
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:28683211
    FAT; FAT domain
  5. XM_006504787.3XP_006504850.1  transformation/transcription domain-associated protein isoform X7

    Conserved Domains (3) summary
    COG5032
    Location:25523893
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:35043817
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:28683211
    FAT; FAT domain
  6. XM_006504784.3XP_006504847.1  transformation/transcription domain-associated protein isoform X2

    Conserved Domains (3) summary
    COG5032
    Location:25523910
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:35213834
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:28683211
    FAT; FAT domain
  7. XM_006504790.3XP_006504853.1  transformation/transcription domain-associated protein isoform X11

    Conserved Domains (2) summary
    COG5032
    Location:25523884
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:35213808
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
  8. XM_030254018.1XP_030109878.1  transformation/transcription domain-associated protein isoform X8

    Conserved Domains (3) summary
    COG5032
    Location:25523892
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:35033816
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:28683211
    FAT; FAT domain
  9. XM_006504793.3XP_006504856.1  transformation/transcription domain-associated protein isoform X15

    Related
    ENSMUSP00000148419.2, ENSMUST00000213013.2
    Conserved Domains (2) summary
    COG5032
    Location:25523866
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:35033790
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
  10. XM_006504786.3XP_006504849.1  transformation/transcription domain-associated protein isoform X4

    Conserved Domains (3) summary
    COG5032
    Location:25523900
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:35113824
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:28683200
    FAT; FAT domain
  11. XM_017320576.2XP_017176065.1  transformation/transcription domain-associated protein isoform X13

    Conserved Domains (3) summary
    COG5032
    Location:25523874
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:35113798
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:28683200
    FAT; FAT domain
  12. XM_017320575.2XP_017176064.1  transformation/transcription domain-associated protein isoform X5

    Conserved Domains (3) summary
    COG5032
    Location:25523899
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:35103823
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:28683200
    FAT; FAT domain
  13. XM_036164690.1XP_036020583.1  transformation/transcription domain-associated protein isoform X12

    Conserved Domains (3) summary
    COG5032
    Location:25523881
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:34923805
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:28583200
    FAT; FAT domain
  14. XM_017320577.2XP_017176066.1  transformation/transcription domain-associated protein isoform X16

    Conserved Domains (3) summary
    COG5032
    Location:25523855
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:34923779
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:28683200
    FAT; FAT domain
  15. XM_011240999.3XP_011239301.1  transformation/transcription domain-associated protein isoform X6

    Conserved Domains (3) summary
    COG5032
    Location:25343893
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:35043817
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:28503193
    FAT; FAT domain
  16. XM_006504788.3XP_006504851.1  transformation/transcription domain-associated protein isoform X9

    Conserved Domains (3) summary
    COG5032
    Location:25273886
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:34973810
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:28433186
    FAT; FAT domain
  17. XM_006504795.3XP_006504858.1  transformation/transcription domain-associated protein isoform X19

    Conserved Domains (3) summary
    COG5032
    Location:25273830
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:34673754
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:28433175
    FAT; FAT domain
  18. XM_006504785.3XP_006504848.1  transformation/transcription domain-associated protein isoform X3

    Conserved Domains (3) summary
    COG5032
    Location:25513910
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:35213834
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:28673210
    FAT; FAT domain
  19. XM_006504792.4XP_006504855.1  transformation/transcription domain-associated protein isoform X14

    Related
    ENSMUSP00000122021.2, ENSMUST00000132925.2
    Conserved Domains (3) summary
    COG5032
    Location:25523873
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:35103797
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:28683200
    FAT; FAT domain
  20. XM_006504794.4XP_006504857.1  transformation/transcription domain-associated protein isoform X17

    Conserved Domains (3) summary
    COG5032
    Location:25273848
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:34853772
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:28433175
    FAT; FAT domain
  21. XM_017320578.3XP_017176067.1  transformation/transcription domain-associated protein isoform X18

    UniProtKB/TrEMBL
    E9QLK7
    Conserved Domains (3) summary
    COG5032
    Location:25263847
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:34843771
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:28423174
    FAT; FAT domain
  22. XM_006504783.4XP_006504846.1  transformation/transcription domain-associated protein isoform X1

    See identical proteins and their annotated locations for XP_006504846.1

    Conserved Domains (3) summary
    COG5032
    Location:25523911
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:35223835
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:28683211
    FAT; FAT domain
  23. XM_030254016.1XP_030109876.1  transformation/transcription domain-associated protein isoform X3

    Conserved Domains (3) summary
    COG5032
    Location:25513910
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:35213834
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:28673210
    FAT; FAT domain

RNA

  1. XR_377190.4 RNA Sequence

  2. XR_377189.4 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_133901.2: Suppressed sequence

    Description
    NM_133901.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.