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IL18BP interleukin 18 binding protein [ Homo sapiens (human) ]

Gene ID: 10068, updated on 13-Mar-2020

Summary

Official Symbol
IL18BPprovided by HGNC
Official Full Name
interleukin 18 binding proteinprovided by HGNC
Primary source
HGNC:HGNC:5987
See related
Ensembl:ENSG00000137496 MIM:604113
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FVH; IL18BPa
Summary
The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
Expression
Broad expression in spleen (RPKM 11.4), appendix (RPKM 6.6) and 24 other tissues See more
Orthologs

Genomic context

See IL18BP in Genome Data Viewer
Location:
11q13.4
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (71997944..72002919)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (71709955..71713965)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene XRCC1 N-terminal domain containing 1-like Neighboring gene olfactory receptor family 7 subfamily E member 126 pseudogene Neighboring gene ring finger protein 121 Neighboring gene uncharacterized LOC100128494 Neighboring gene nuclear mitotic apparatus protein 1 Neighboring gene Sharpr-MPRA regulatory region 3523

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
interleukin-18 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-18 binding IDA
Inferred from Direct Assay
more info
PubMed 
receptor antagonist activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
T-helper 1 type immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
T-helper 1 type immune response IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to cytokine stimulus TAS
Traceable Author Statement
more info
 
interleukin-18-mediated signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
interleukin-18-binding protein
Names
MC51L-53L-54L homolog gene product
tadekinig-alfa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029021.1 RefSeqGene

    Range
    5001..8617
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001039659.1NP_001034748.1  interleukin-18-binding protein isoform a precursor

    See identical proteins and their annotated locations for NP_001034748.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (E) differs in the 5' UTR compared to variant A. Variants A, E, F and G encode the same isoform (a, also known as IL-18BPa).
    Source sequence(s)
    AF110799, AW295729, BX357194
    Consensus CDS
    CCDS8206.2
    UniProtKB/Swiss-Prot
    O95998
    UniProtKB/TrEMBL
    A0A024R5G2
    Related
    ENSP00000377308.4, ENST00000393705.8
    Conserved Domains (1) summary
    cl23951
    Location:79169
    Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein
  2. NM_001039660.2NP_001034749.1  interleukin-18-binding protein isoform a precursor

    See identical proteins and their annotated locations for NP_001034749.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (F) differs in the 5' UTR compared to variant A. Variants A, E, F and G encode the same isoform (a, also known as IL-18BPa).
    Source sequence(s)
    AF110799, AP002490, AW295729, BX357194, CB154498
    Consensus CDS
    CCDS8206.2
    UniProtKB/Swiss-Prot
    O95998
    UniProtKB/TrEMBL
    A0A024R5G2
    Related
    ENSP00000377306.4, ENST00000393703.9
    Conserved Domains (1) summary
    cl23951
    Location:79169
    Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein
  3. NM_001145055.1NP_001138527.1  interleukin-18-binding protein isoform b precursor

    See identical proteins and their annotated locations for NP_001138527.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (H) lacks two internal exons in the 3' coding region compared to variant A, which results in a frame-shift and a shorter isoform (b, also known as IL-18BPb) with a distinct C-terminus compared to isoform a. This isoform lacks the ability to bind IL-18 (PMID:10655506).
    Source sequence(s)
    AF110800, AW295729
    Consensus CDS
    CCDS44666.1
    UniProtKB/Swiss-Prot
    O95998
    UniProtKB/TrEMBL
    A0A024R5M7
    Related
    ENSP00000377310.4, ENST00000393707.4
  4. NM_001145057.1NP_001138529.1  interleukin-18-binding protein isoform a precursor

    See identical proteins and their annotated locations for NP_001138529.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (G) differs in the 5' UTR compared to variant A. Variants A, E, F and G encode the same isoform (a, also known as IL-18BPa).
    Source sequence(s)
    AF122906, AW295729, BM819966
    Consensus CDS
    CCDS8206.2
    UniProtKB/Swiss-Prot
    O95998
    UniProtKB/TrEMBL
    A0A024R5G2
    Related
    ENSP00000260049.5, ENST00000260049.9
    Conserved Domains (1) summary
    cl23951
    Location:79169
    Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein
  5. NM_005699.3NP_005690.2  interleukin-18-binding protein isoform c precursor

    See identical proteins and their annotated locations for NP_005690.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (C) is alternatively spliced in the 3' coding region compared to variant A. This results in a frame-shift, and a longer isoform (c, also known as IL-18BPc) with a distinct C-terminus compared to isoform a. This isoform retains the ability to bind IL-18 (PMID:10655506).
    Source sequence(s)
    AF110799, AF110801, AL698586
    Consensus CDS
    CCDS8207.2
    UniProtKB/Swiss-Prot
    O95998
    UniProtKB/TrEMBL
    G3V1C5
    Related
    ENSP00000434717.1, ENST00000497194.6
    Conserved Domains (1) summary
    cl23951
    Location:79169
    Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein
  6. NM_173042.2NP_766630.2  interleukin-18-binding protein isoform a precursor

    See identical proteins and their annotated locations for NP_766630.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (A) encodes the predominant isoform (a, also known as IL-18BPa), which shows the highest affinity for binding IL-18 (PMID:10655506). Variants A, E, F and G encode the same isoform.
    Source sequence(s)
    AF110799, AF110801, AW295729
    Consensus CDS
    CCDS8206.2
    UniProtKB/Swiss-Prot
    O95998
    UniProtKB/TrEMBL
    A0A024R5G2
    Related
    ENSP00000384212.1, ENST00000404792.5
    Conserved Domains (1) summary
    cl23951
    Location:79169
    Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein
  7. NM_173044.2NP_766632.2  interleukin-18-binding protein isoform d precursor

    See identical proteins and their annotated locations for NP_766632.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (D) differs in the 5' UTR and uses an alternate donor splice site at the penultimate coding exon compared to variant A. This results in a frame-shift and a shorter isoform (d, also known as IL-18BPd) with a distinct C-terminus compared to isoform a. This isoform lacks the ability to bind IL-18 (PMID:10655506).
    Source sequence(s)
    AF215907, CB154498
    UniProtKB/Swiss-Prot
    O95998
    UniProtKB/TrEMBL
    A0A024R5I1
    Related
    ENSP00000480621.1, ENST00000620017.4
    Conserved Domains (1) summary
    cl23951
    Location:79122
    Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    71997944..72002919
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448304.1XP_024304072.1  interleukin-18-binding protein isoform X1

    Conserved Domains (1) summary
    cl23951
    Location:79169
    Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein
  2. XM_017017063.1XP_016872552.1  interleukin-18-binding protein isoform X1

    UniProtKB/Swiss-Prot
    O95998
    UniProtKB/TrEMBL
    A0A024R5G2
    Conserved Domains (1) summary
    cl23951
    Location:79169
    Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein
  3. XM_024448303.1XP_024304071.1  interleukin-18-binding protein isoform X1

    Conserved Domains (1) summary
    cl23951
    Location:79169
    Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein
  4. XM_017017059.1XP_016872548.1  interleukin-18-binding protein isoform X1

    UniProtKB/Swiss-Prot
    O95998
    UniProtKB/TrEMBL
    A0A024R5G2
    Conserved Domains (1) summary
    cl23951
    Location:79169
    Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein
  5. XM_017017062.1XP_016872551.1  interleukin-18-binding protein isoform X1

    UniProtKB/Swiss-Prot
    O95998
    UniProtKB/TrEMBL
    A0A024R5G2
    Conserved Domains (1) summary
    cl23951
    Location:79169
    Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein
  6. XM_017017061.2XP_016872550.1  interleukin-18-binding protein isoform X1

    UniProtKB/Swiss-Prot
    O95998
    UniProtKB/TrEMBL
    A0A024R5G2
    Conserved Domains (1) summary
    cl23951
    Location:79169
    Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein
  7. XM_017017060.1XP_016872549.1  interleukin-18-binding protein isoform X1

    UniProtKB/Swiss-Prot
    O95998
    UniProtKB/TrEMBL
    A0A024R5G2
    Conserved Domains (1) summary
    cl23951
    Location:79169
    Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_173043.1: Suppressed sequence

    Description
    NM_173043.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
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