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TPH2 tryptophan hydroxylase 2 [ Sus scrofa (pig) ]

Gene ID: 100627725, updated on 26-Jun-2026
Official Symbol
TPH2provided by VGNC
Official Full Name
tryptophan hydroxylase 2provided by VGNC
Primary source
VGNC:VGNC:94336
See related
Ensembl:ENSSSCG00000021122 RGD:14039074
Gene type
protein coding
RefSeq status
MODEL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Low expression observed in reference dataset See more
Orthologs
all
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See TPH2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2026_06 current Sscrofa_HxYL_maternal_Yorkshire_Landrace_v2.0 (GCF_054392235.1) 5 NC_139387.1 (39852091..39957091)
106 previous assembly Sscrofa11.1 (GCF_000003025.6) 5 NC_010447.5 (35917159..36016981)

Chromosome 5 - NC_139387.1Genomic Context describing neighboring genes Neighboring gene nuclear nucleic acid-binding protein C1D pseudogene Neighboring gene uncharacterized LOC146403335 Neighboring gene TBC1 domain family member 15 Neighboring gene E3 ubiquitin-protein ligase RNF114 pseudogene Neighboring gene thyrotropin releasing hormone degrading enzyme Neighboring gene uncharacterized LOC110260707 Neighboring gene large ribosomal subunit protein eL21 pseudogene

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables tryptophan 5-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in aromatic amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in serotonin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
tryptophan 5-hydroxylase 2

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RefSeqs of Annotated Genomes: GCF_054392235.1-RS_2026_06

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa_HxYL_maternal_Yorkshire_Landrace_v2.0

Genomic

  1. NC_139387.1 Reference Sscrofa_HxYL_maternal_Yorkshire_Landrace_v2.0

    Range
    39852091..39957091
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_084956354.1 → XP_084812480.1  tryptophan 5-hydroxylase 2 isoform X2

  2. XM_084956353.1 → XP_084812479.1  tryptophan 5-hydroxylase 2 isoform X2

  3. XM_021092003.2 → XP_020947662.1  tryptophan 5-hydroxylase 2 isoform X1

    UniProtKB/TrEMBL
    F1SH22
    Related
    ENSSSCP00000000543.3
    Conserved Domains (2) summary
    pfam00351
    Location:153 → 483
    Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase
    cl09141
    Location:65 → 138
    ACT; ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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