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PCSK9 proprotein convertase subtilisin/kexin type 9 [ Sus scrofa (pig) ]

Gene ID: 100620501, updated on 8-Mar-2024

Summary

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Official Symbol
PCSK9provided by VGNC
Official Full Name
proprotein convertase subtilisin/kexin type 9provided by VGNC
Primary source
VGNC:VGNC:91234
See related
Ensembl:ENSSSCG00000025020
Gene type
protein coding
RefSeq status
MODEL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Biased expression in liver (RPKM 35.2) and mixtures (RPKM 12.4) See more
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
12
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 6 NC_010448.4 (157388370..157409620, complement)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 6 NC_010448.3 (145451983..145473336, complement)

Chromosome 6 - NC_010448.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110261421 Neighboring gene ubiquitin specific peptidase 24 Neighboring gene barttin CLCNK type accessory subunit beta Neighboring gene transmembrane protein 61

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Porcine Reproductive and Respiratory Syndrome Virus Antagonizes PCSK9's Antiviral Effect via Nsp11 Endoribonuclease Activity. Zhang Y, et al. Viruses, 2020 Jun 17. PMID 32560445, Free PMC Article
  2. Peripheral vascular atherosclerosis in a novel PCSK9 gain-of-function mutant Ossabaw miniature pig model. Hedayat AF, et al. Transl Res, 2018 Feb. PMID 29175268, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Porcine Reproductive and Respiratory Syndrome Virus Antagonizes PCSK9's Antiviral Effect via Nsp11 Endoribonuclease Activity.
    Title: Porcine Reproductive and Respiratory Syndrome Virus Antagonizes PCSK9's Antiviral Effect via Nsp11 Endoribonuclease Activity.
  2. the PCSK9-gain-of-function mutation induces rapid development of atherosclerosis in peripheral vessels of Ossabaw pigs, which is exacerbated by a high-cholesterol diet.
    Title: Peripheral vascular atherosclerosis in a novel PCSK9 gain-of-function mutant Ossabaw miniature pig model.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
LOW QUALITY PROTEIN: proprotein convertase subtilisin/kexin type 9

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010448.4 Reference Sscrofa11.1 Primary Assembly

    Range
    157388370..157409620 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005653438.3 → XP_005653495.2  LOW QUALITY PROTEIN: proprotein convertase subtilisin/kexin type 9

    UniProtKB/TrEMBL
    A0A8D1DPA1
    Related
    ENSSSCP00000023105.3, ENSSSCT00000029382.4
    Conserved Domains (3) summary
    cd04077
    Location:154 → 432
    Peptidases_S8_PCSK9_ProteinaseK_like; Peptidase S8 family domain in ProteinaseK-like proteins
    pfam05922
    Location:75 → 147
    Inhibitor_I9; Peptidase inhibitor I9
    cd16839
    Location:463 → 694
    PCSK9_C-CRD; proprotein convertase subtilisin/kexin type 9, C-terminal cysteine-rich domain (CRD)
Nucleotide Protein
Heading Accession and Version

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