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Slc15a4 solute carrier family 15, member 4 [ Mus musculus (house mouse) ]

Gene ID: 100561, updated on 12-May-2024

Summary

Official Symbol
Slc15a4provided by MGI
Official Full Name
solute carrier family 15, member 4provided by MGI
Primary source
MGI:MGI:2140796
See related
Ensembl:ENSMUSG00000029416 AllianceGenome:MGI:2140796
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PHT1; PTR4; C130069N12Rik
Summary
Enables L-histidine transmembrane transporter activity and peptide:proton symporter activity. Involved in several processes, including L-histidine transmembrane export from vacuole; positive regulation of pattern recognition receptor signaling pathway; and regulation of isotype switching to IgG isotypes. Located in early endosome membrane and lysosomal membrane. Is integral component of endosome membrane and integral component of lysosomal membrane. Is expressed in embryo. Orthologous to human SLC15A4 (solute carrier family 15 member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 27.6), mammary gland adult (RPKM 16.0) and 28 other tissues See more
Orthologs
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Genomic context

See Slc15a4 in Genome Data Viewer
Location:
5 G1.2; 5 66.0 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (127668795..127710356, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (127594545..127633292, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 132C, opposite strand Neighboring gene transmembrane protein 132C Neighboring gene predicted gene, 54294 Neighboring gene STARR-seq mESC enhancer starr_14401 Neighboring gene STARR-seq mESC enhancer starr_14404 Neighboring gene STARR-seq mESC enhancer starr_14405 Neighboring gene STARR-seq mESC enhancer starr_14412 Neighboring gene STARR-seq mESC enhancer starr_14414 Neighboring gene glycosyltransferase 1 domain containing 1 Neighboring gene transmembrane protein 132D Neighboring gene STARR-seq mESC enhancer starr_14415 Neighboring gene STARR-seq mESC enhancer starr_14419 Neighboring gene predicted gene, 33738

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in L-histidine transmembrane export from vacuole IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dipeptide import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in dipeptide import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in histidine transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in histidine transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in mast cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in oligopeptide transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within peptide transport IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidoglycan transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidoglycan transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidoglycan transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of toll-like receptor 7 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of toll-like receptor 7 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of toll-like receptor 8 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of toll-like receptor 9 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of toll-like receptor 9 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of isotype switching to IgG isotypes IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in early endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endolysosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
solute carrier family 15 member 4
Names
peptide transporter 4
peptide-histidine transporter 4
peptide/histidine transporter 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133895.1NP_598656.1  solute carrier family 15 member 4

    See identical proteins and their annotated locations for NP_598656.1

    Status: PROVISIONAL

    Source sequence(s)
    BC016233
    Consensus CDS
    CCDS19688.1
    UniProtKB/Swiss-Prot
    Q7TPL5, Q91W98
    Related
    ENSMUSP00000031367.9, ENSMUST00000031367.15
    Conserved Domains (1) summary
    pfam00854
    Location:146519
    PTR2; POT family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    127668795..127710356 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504272.5XP_006504335.1  solute carrier family 15 member 4 isoform X2

    Conserved Domains (1) summary
    cl28910
    Location:16388
    MFS; Major Facilitator Superfamily
  2. XM_006504271.4XP_006504334.1  solute carrier family 15 member 4 isoform X1

    Conserved Domains (1) summary
    cl28910
    Location:27504
    MFS; Major Facilitator Superfamily

RNA

  1. XR_004942415.1 RNA Sequence

  2. XR_004942414.1 RNA Sequence

  3. XR_003955563.2 RNA Sequence

  4. XR_001784584.3 RNA Sequence