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pkd1l2b polycystic kidney disease 1 like 2b [ Danio rerio (zebrafish) ]

Gene ID: 100537993, updated on 4-Jan-2025

Summary

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Official Symbol
pkd1l2bprovided by ZNC
Official Full Name
polycystic kidney disease 1 like 2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-141222-87
See related
Ensembl:ENSDARG00000101214 AllianceGenome:ZFIN:ZDB-GENE-141222-87
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
pkd1l2; si:ch1073-128e6.1; si:ch211-168k15.4; si:ch211-168k15.5
Summary
Predicted to enable calcium channel activity. Predicted to be involved in detection of mechanical stimulus. Predicted to be active in membrane. Is expressed in amacrine cell; ceratobranchial cartilage; pharyngeal arch cartilage; pharynx; and retinal ganglion cell layer. Orthologous to several human genes including PKD1L2 (polycystin 1 like 2 (gene/pseudogene)). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See pkd1l2b in Genome Data Viewer
Location:
chromosome: 7
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (67252880..67310709)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (67037490..67086430)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene switching B cell complex subunit SWAP70a Neighboring gene zinc finger protein 143a Neighboring gene proteasome 26S subunit, non-ATPase 7 Neighboring gene nuclear factor of activated T cells 5b Neighboring gene lysyl-tRNA synthetase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification and Expression Analysis of the Complete Family of Zebrafish pkd Genes. England SJ, et al. Front Cell Dev Biol, 2017. PMID 28271061, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in detection of mechanical stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
polycystin-1-like protein 2
Names
polycystic kidney disease protein 1-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    67252880..67310709
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021478036.1 → XP_021333711.1  polycystin-1-like protein 2

    UniProtKB/TrEMBL
    A0A3G1GT98, E7F2U9
    Related
    ENSDARP00000105814.3, ENSDART00000124969.3
    Conserved Domains (5) summary
    cd00037
    Location:33 → 150
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    cd01752
    Location:869 → 988
    PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...
    pfam01825
    Location:759 → 798
    GPS; GPCR proteolysis site, GPS, motif
    pfam02140
    Location:164 → 245
    Gal_Lectin; Galactose binding lectin domain
    cl27887
    Location:1437 → 1860
    PKD_channel; Polycystin cation channel

RNA

  1. XR_002459313.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Research Materials