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chrna8 cholinergic receptor, nicotinic, alpha 8 [ Danio rerio (zebrafish) ]

Gene ID: 100537531, updated on 14-Nov-2024

Summary

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Official Symbol
chrna8provided by ZNC
Official Full Name
cholinergic receptor, nicotinic, alpha 8provided by ZNC
Primary source
ZFIN:ZDB-GENE-090313-161
See related
Ensembl:ENSDARG00000087224 AllianceGenome:ZFIN:ZDB-GENE-090313-161
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch73-380n15.2
Summary
Predicted to enable excitatory extracellular ligand-gated monoatomic ion channel activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in chemical synaptic transmission; monoatomic ion transmembrane transport; and regulation of membrane potential. Predicted to act upstream of or within monoatomic ion transport. Predicted to be located in postsynaptic membrane. Predicted to be part of acetylcholine-gated channel complex. Predicted to be active in neuron projection; plasma membrane; and synapse. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See chrna8 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (22236312..22371136, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (21542754..21591160, complement)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene dynein, axonemal, heavy chain 6 Neighboring gene uncharacterized LOC110439140 Neighboring gene uncharacterized LOC103908754 Neighboring gene uncharacterized LOC137495489 Neighboring gene cholinergic receptor nicotinic beta 3 subunit a Neighboring gene DNA ligase 1-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables acetylcholine-gated monoatomic cation-selective channel activity IEA
Inferred from Electronic Annotation
more info
  
enables extracellular ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CHRNA7-FAM7A fusion protein; neuronal acetylcholine receptor subunit alpha-7

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    22236312..22371136 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021476327.2 → XP_021332002.1  neuronal acetylcholine receptor subunit alpha-7 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PEJ8
    Related
    ENSDARP00000144302.2, ENSDART00000176849.2
    Conserved Domains (1) summary
    cl27321
    Location:12 → 504
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394479.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    291962..316687 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021471189.2 → XP_021326864.1  CHRNA7-FAM7A fusion protein isoform X2

    UniProtKB/TrEMBL
    A0A8M9PPT6
    Conserved Domains (1) summary
    cl27321
    Location:4 → 317
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395213.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    137064..261045 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021473897.2 → XP_021329572.1  neuronal acetylcholine receptor subunit alpha-7 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PEJ8
    Conserved Domains (1) summary
    cl27321
    Location:12 → 504
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
Nucleotide Protein Strain
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