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mhc1lga major histocompatibility complex class I LGA [ Danio rerio (zebrafish) ]

Gene ID: 100535946, updated on 9-Dec-2024

Summary

Official Symbol
mhc1lgaprovided by ZNC
Official Full Name
major histocompatibility complex class I LGAprovided by ZNC
Primary source
ZFIN:ZDB-GENE-140820-8
See related
Ensembl:ENSDARG00000051713 AllianceGenome:ZFIN:ZDB-GENE-140820-8
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
mhc1lia; si:dkey-52p2.6
Summary
Predicted to be involved in immune response. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane and extracellular space. Human ortholog(s) of this gene implicated in pulmonary tuberculosis. Orthologous to several human genes including CD1A (CD1a molecule); CD1B (CD1b molecule); and CD1C (CD1c molecule). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See mhc1lga in Genome Data Viewer
Location:
chromosome: 25
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (11002640..11006571)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (10905808..10909775)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene major histocompatibility complex class I LLA Neighboring gene si:dkey-52p2.5 Neighboring gene major histocompatibility complex class I LIA Neighboring gene mesoderm posterior ab

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
major histocompatibility complex class I LGA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001327884.1NP_001314813.1  major histocompatibility complex class I LGA precursor

    Status: VALIDATED

    Source sequence(s)
    CR854891, EH434256
    UniProtKB/TrEMBL
    A0A8M1P8F9, F1RAH2
    Related
    ENSDARP00000067874.5, ENSDART00000073383.5
    Conserved Domains (1) summary
    cd07698
    Location:198294
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    11002640..11006571
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)