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FXYD6-FXYD2 FXYD6-FXYD2 readthrough [ Homo sapiens (human) ]

Gene ID: 100533181, updated on 11-Jun-2021

Summary

Official Symbol
FXYD6-FXYD2provided by HGNC
Official Full Name
FXYD6-FXYD2 readthroughprovided by HGNC
Primary source
HGNC:HGNC:39978
See related
Ensembl:ENSG00000255245
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FXYD6
Summary
This locus represents naturally occurring read-through transcription between the neighboring FXYD domain-containing ion transport regulator 6 (GeneID 53826) and sodium/potassium-transporting ATPase subunit gamma (GeneID 486) genes on chromosome 11. One read-through transcript produces a fusion protein that shares sequence identity with each individual gene product, while another read-through transcript encodes a protein that has a distinct C-terminus and only shares sequence identity with the upstream locus (GeneID 53826). [provided by RefSeq, Aug 2011]
Expression
Biased expression in kidney (RPKM 274.3), brain (RPKM 65.1) and 6 other tissues See more
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Genomic context

See FXYD6-FXYD2 in Genome Data Viewer
Location:
11q23.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (117820057..117876658, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (117690772..117747373, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene DS cell adhesion molecule like 1 Neighboring gene uncharacterized LOC105369515 Neighboring gene uncharacterized LOC107984394 Neighboring gene FXYD domain containing ion transport regulator 2 Neighboring gene FXYD domain containing ion transport regulator 6 Neighboring gene transmembrane serine protease 13 Neighboring gene interleukin 10 receptor subunit alpha Neighboring gene small integral membrane protein 35

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
FXYD6-FXYD2 read-through protein
Names
FXYD domain-containing ion transport regulator 6
Phosphohippolin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204268.3NP_001191197.1  FXYD6-FXYD2 read-through protein isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AP000757, FY211982, FY214031
    UniProtKB/TrEMBL
    A0A087WZ82
    Related
    ENSP00000482442.1, ENST00000614497.5
    Conserved Domains (1) summary
    pfam02038
    Location:2570
    ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family
  2. NM_001243598.4NP_001230527.1  FXYD6-FXYD2 read-through protein isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AP000757, CN310658
    UniProtKB/TrEMBL
    A0A0A6YYL5
    Related
    ENSP00000463024.1, ENST00000532984.1
    Conserved Domains (1) summary
    pfam02038
    Location:2557
    ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    117820057..117876658 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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