U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MICOS10-NBL1 MICOS10-NBL1 readthrough [ Homo sapiens (human) ]

Gene ID: 100532736, updated on 17-Feb-2024

Summary

Go to the top of the page Help
Official Symbol
MICOS10-NBL1provided by HGNC
Official Full Name
MICOS10-NBL1 readthroughprovided by HGNC
Primary source
HGNC:HGNC:48338
See related
Ensembl:ENSG00000158747 AllianceGenome:HGNC:48338
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DAN; NBL1; DAND1; MINOS1-NBL1; C1orf151-NBL1
Summary
This locus represents naturally occurring read-through transcription between the neighboring chromosome 1 open reading frame 151 (GeneID 440574) and neuroblastoma suppressor of tumorigenicity 1 (GeneID 4681) genes on chromosome 1. The read-through transcripts produce at least two proteins, each of which share identity with proteins translated from the downstream neuroblastoma suppressor of tumorigenicity 1 locus. [provided by RefSeq, Feb 2011]
Expression
Broad expression in ovary (RPKM 169.7), prostate (RPKM 148.1) and 20 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
1p36.13
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (19596979..19658452)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (19420423..19481830)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (19923473..19984945)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene MPRA-validated peak99 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr1:19896756-19897005 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 305 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 357 Neighboring gene MICOS10 divergent transcript Neighboring gene mitochondrial contact site and cristae organizing system subunit 10 Neighboring gene ribosomal protein S14 pseudogene 3 Neighboring gene MPRA-validated peak101 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr1:19962230-19962437 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:19969817-19970652 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:19976919-19977536 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 359 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:19991190-19992162 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:19992163-19993133 Neighboring gene NBL1, DAN family BMP antagonist Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:20015541-20016055 Neighboring gene 5-hydroxytryptamine receptor 6 Neighboring gene transmembrane and coiled-coil domains 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:20066909-20067410 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:20067411-20067910 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:20076458-20077657 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:20091493-20092692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:20106613-20107114 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 306 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 307 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:20126577-20127077

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Structure of neuroblastoma suppressor of tumorigenicity 1 (NBL1): insights for the functional variability across bone morphogenetic protein (BMP) antagonists. Nolan K, et al. J Biol Chem, 2015 Feb 20. PMID 25561725, Free PMC Article
  2. Purification and partial amino acid sequence of proteins from human epidermal keratinocyte conditioned medium. Ahmed A, et al. J Protein Chem, 2001 May. PMID 11594460
  3. Members of the DAN family are BMP antagonists that form highly stable noncovalent dimers. Kattamuri C, et al. J Mol Biol, 2012 Dec 14. PMID 23063586, Free PMC Article
  4. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. Prakash T, et al. PLoS One, 2010 Oct 12. PMID 20967262, Free PMC Article
  5. Mapping the Genetic Landscape of Human Cells. Horlbeck MA, et al. Cell, 2018 Aug 9. PMID 30033366, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ45636

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables BMP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables BMP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables identical protein binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables morphogen activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables receptor ligand activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in determination of dorsal identity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of BMP signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of monocyte chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in nervous system development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neuron projection morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in sequestering of BMP from receptor via BMP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sequestering of BMP from receptor via BMP binding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sequestering of BMP in extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IC
Inferred by Curator
more info
 PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
neuroblastoma suppressor of tumorigenicity 1
Names
C1orf151-NBL1 read-through protein
DAN domain family member 1
MICOS10-NBL1 read-through protein
MINOS1-NBL1 readthrough
Protein N03
Zinc finger protein DAN

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204088.2 → NP_001191017.1  neuroblastoma suppressor of tumorigenicity 1 isoform a precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK289456, AL031727, FY212253
    UniProtKB/TrEMBL
    E5RFZ1
    Conserved Domains (1) summary
    pfam03045
    Location:37 → 135
    DAN; DAN domain

  2. NM_001204089.2 → NP_001191018.1  neuroblastoma suppressor of tumorigenicity 1 isoform b precursor

    See identical proteins and their annotated locations for NP_001191018.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AK289456, AL031727
    UniProtKB/Swiss-Prot
    A3KFI7, P41271, Q5TGZ2, Q5U0N4, Q96L68
    UniProtKB/TrEMBL
    E5RFZ1
    Related
    ENSP00000473411.1, ENST00000602662.1
    Conserved Domains (1) summary
    pfam03045
    Location:23 → 121
    DAN; DAN domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    19596979..19658452
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    19420423..19481830
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41271.2 GenPept UniProtKB/Swiss-Prot:P41271

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Miscellaneous