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CHURC1-FNTB CHURC1-FNTB readthrough [ Homo sapiens (human) ]

Gene ID: 100529261, updated on 5-Jan-2022

Summary

Official Symbol
CHURC1-FNTBprovided by HGNC
Official Full Name
CHURC1-FNTB readthroughprovided by HGNC
Primary source
HGNC:HGNC:42960
See related
Ensembl:ENSG00000125954
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FNTB; FTase-beta
Summary
This locus represents naturally occurring read-through transcription between the neighboring CHURC1 (churchill domain containing 1) and FNTB (farnesyltransferase, CAAX box, beta) on chromosome 14. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Feb 2011]
Expression
Ubiquitous expression in testis (RPKM 10.7), brain (RPKM 10.1) and 25 other tissues See more
Orthologs
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Genomic context

See CHURC1-FNTB in Genome Data Viewer
Location:
14q23.3
Exon count:
14
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (64914361..65062655)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (65381079..65529373)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370534 Neighboring gene ribonuclease P RNA component H1, 2 pseudogene Neighboring gene churchill domain containing 1 Neighboring gene glutathione peroxidase 2 Neighboring gene RAB15, member RAS oncogene family Neighboring gene uncharacterized LOC107984655 Neighboring gene farnesyltransferase, CAAX box, beta Neighboring gene MYC associated factor X Neighboring gene microRNA 4706 Neighboring gene uncharacterized LOC100506321 Neighboring gene RNA, U2 small nuclear 14, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
EBI GWAS Catalog
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.
EBI GWAS Catalog
Seventy-five genetic loci influencing the human red blood cell.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ58825, FLJ59570

General protein information

Preferred Names
CHURC1-FNTB protein
Names
CAAX farnesyltransferase subunit beta
Protein farnesyltransferase subunit beta
Ras proteins prenyltransferase subunit beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001202558.2NP_001189487.1  CHURC1-FNTB protein isoform 2

    See identical proteins and their annotated locations for NP_001189487.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region and uses a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK303739, AL135745, AL139022
    UniProtKB/Swiss-Prot
    P49356
    Conserved Domains (2) summary
    PLN02710
    Location:4373
    PLN02710; farnesyltranstransferase subunit beta
    cd02893
    Location:29327
    FTase; Protein farnesyltransferase (FTase)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). FTases are a subgroup of PTase family of lipid-modifying enzymes. PTases catalyze the ...
  2. NM_001202559.1NP_001189488.1  CHURC1-FNTB protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK296850, AL135745, AL139022
    UniProtKB/TrEMBL
    B4DL54
    Related
    ENSP00000447121.2, ENST00000549987.1
    Conserved Domains (3) summary
    PLN02710
    Location:109480
    PLN02710; farnesyltranstransferase subunit beta
    cd02893
    Location:136434
    FTase; Protein farnesyltransferase (FTase)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). FTases are a subgroup of PTase family of lipid-modifying enzymes. PTases catalyze the ...
    pfam06573
    Location:28109
    Churchill; Churchill protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    64914361..65062655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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