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BCL2L2-PABPN1 BCL2L2-PABPN1 readthrough [ Homo sapiens (human) ]

Gene ID: 100529063, updated on 12-Aug-2022

Summary

Official Symbol
BCL2L2-PABPN1provided by HGNC
Official Full Name
BCL2L2-PABPN1 readthroughprovided by HGNC
Primary source
HGNC:HGNC:42959
See related
Ensembl:ENSG00000258643 AllianceGenome:HGNC:42959
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This locus represents naturally occurring read-through transcription between the neighboring BCL2L2 (BCL2-like 2) and PABPN1 (poly(A) binding protein, nuclear 1) genes on chromosome 14. The read-through transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Dec 2010]
Expression
Ubiquitous expression in testis (RPKM 56.2), prostate (RPKM 46.1) and 25 other tissues See more
Orthologs
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Genomic context

See BCL2L2-PABPN1 in Genome Data Viewer
Location:
14q11.2
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (23306833..23326163)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (17507847..17527178)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (23776042..23795372)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ring finger protein 212B Neighboring gene homeobox and leucine zipper encoding Neighboring gene protein phosphatase 1 regulatory subunit 3E Neighboring gene H3 histone pseudogene 37 Neighboring gene BCL2 like 2 Neighboring gene poly(A) binding protein nuclear 1 Neighboring gene solute carrier family 22 member 17 Neighboring gene embryonal Fyn-associated substrate

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199864.3NP_001186793.2  BCL2L2-PABPN1 protein isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL049829
    Related
    ENSP00000451320.1, ENST00000553781.5
    Conserved Domains (2) summary
    cd12550
    Location:200275
    RRM_II_PABPN1; RNA recognition motif in type II polyadenylate-binding protein 2 (PABP-2) and similar proteins
    TIGR00865
    Location:11145
    bcl-2; apoptosis regulator
  2. NM_001387340.1NP_001374269.1  BCL2L2-PABPN1 protein isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL049829
    Conserved Domains (2) summary
    TIGR00865
    Location:11185
    bcl-2; apoptosis regulator
    cd12550
    Location:239314
    RRM_II_PABPN1; RNA recognition motif in type II polyadenylate-binding protein 2 (PABP-2) and similar proteins
  3. NM_001387341.1NP_001374270.1  BCL2L2-PABPN1 protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL049829
    UniProtKB/TrEMBL
    A0A7I2V383
    Related
    ENSP00000503309.1, ENST00000678502.1
    Conserved Domains (2) summary
    TIGR00865
    Location:11144
    bcl-2; apoptosis regulator
    cd12550
    Location:232307
    RRM_II_PABPN1; RNA recognition motif in type II polyadenylate-binding protein 2 (PABP-2) and similar proteins
  4. NM_001387342.1NP_001374271.1  BCL2L2-PABPN1 protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL049829
    UniProtKB/TrEMBL
    A0A7I2V383
    Conserved Domains (2) summary
    TIGR00865
    Location:11144
    bcl-2; apoptosis regulator
    cd12550
    Location:232307
    RRM_II_PABPN1; RNA recognition motif in type II polyadenylate-binding protein 2 (PABP-2) and similar proteins
  5. NM_001387343.1NP_001374272.1  BCL2L2-PABPN1 protein isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL049829
    Conserved Domains (2) summary
    TIGR00865
    Location:11144
    bcl-2; apoptosis regulator
    cd12550
    Location:232307
    RRM_II_PABPN1; RNA recognition motif in type II polyadenylate-binding protein 2 (PABP-2) and similar proteins
  6. NM_001387344.1NP_001374273.1  BCL2L2-PABPN1 protein isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL049829
    Conserved Domains (2) summary
    TIGR00865
    Location:11144
    bcl-2; apoptosis regulator
    cd12550
    Location:232307
    RRM_II_PABPN1; RNA recognition motif in type II polyadenylate-binding protein 2 (PABP-2) and similar proteins
  7. NM_001387345.1NP_001374274.1  BCL2L2-PABPN1 protein isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL049829
    Conserved Domains (2) summary
    TIGR00865
    Location:11145
    bcl-2; apoptosis regulator
    cd12550
    Location:200275
    RRM_II_PABPN1; RNA recognition motif in type II polyadenylate-binding protein 2 (PABP-2) and similar proteins
  8. NM_001387346.1NP_001374275.1  BCL2L2-PABPN1 protein isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL049829
    Conserved Domains (2) summary
    TIGR00865
    Location:11145
    bcl-2; apoptosis regulator
    cd12550
    Location:200275
    RRM_II_PABPN1; RNA recognition motif in type II polyadenylate-binding protein 2 (PABP-2) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    23306833..23326163
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    17507847..17527178
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)