Format

Send to:

Choose Destination

KLRC4-KLRK1 KLRC4-KLRK1 readthrough [ Homo sapiens (human) ]

Gene ID: 100528032, updated on 24-Nov-2020

Summary

Official Symbol
KLRC4-KLRK1provided by HGNC
Official Full Name
KLRC4-KLRK1 readthroughprovided by HGNC
Primary source
HGNC:HGNC:48357
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This locus represents naturally occurring read-through transcription between the neighboring KLRC4 (killer cell lectin-like receptor subfamily C, member 4) and KLRK1 (killer cell lectin-like receptor subfamily K, member 1) genes on chromosome 12. The read-through transcript includes an alternate 5' exon and lacks a significant portion of the KLRC4 coding sequence, including the start codon, and it thus encodes the KLRK1 protein. [provided by RefSeq, Dec 2010]
Expression
Broad expression in spleen (RPKM 24.6), lymph node (RPKM 18.8) and 16 other tissues See more
Orthologs

Genomic context

See KLRC4-KLRK1 in Genome Data Viewer
Location:
12p13.2
Exon count:
13
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (10372353..10410146, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (10524952..10562745, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2617 Neighboring gene long intergenic non-protein coding RNA 2598 Neighboring gene KLRK1 antisense RNA 1 Neighboring gene killer cell lectin like receptor K1 Neighboring gene killer cell lectin like receptor C4 Neighboring gene killer cell lectin like receptor C3 Neighboring gene killer cell lectin like receptor C2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1.
GeneReviews: Not available

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • FLJ17759, FLJ78582

Gene Ontology Provided by GOA

Function Evidence Code Pubs
MHC class I protein binding IEA
Inferred from Electronic Annotation
more info
 
MHC class Ib receptor activity IEA
Inferred from Electronic Annotation
more info
 
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
T cell costimulation TAS
Traceable Author Statement
more info
PubMed 
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
defense response to Gram-positive bacterium IEA
Inferred from Electronic Annotation
more info
 
natural killer cell activation TAS
Traceable Author Statement
more info
PubMed 
natural killer cell mediated cytotoxicity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of natural killer cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interferon-gamma production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of natural killer cell mediated cytotoxicity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of natural killer cell mediated cytotoxicity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of nitric oxide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
regulation of immune response TAS
Traceable Author Statement
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
stimulatory C-type lectin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
NKG2-D type II integral membrane protein
Names
NK cell receptor D
NKG2-D-activating NK receptor
killer cell lectin-like receptor subfamily K member 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199805.1NP_001186734.1  NKG2-D type II integral membrane protein

    See identical proteins and their annotated locations for NP_001186734.1

    Status: VALIDATED

    Source sequence(s)
    AC022075, AF461811
    UniProtKB/Swiss-Prot
    P26718
    UniProtKB/TrEMBL
    A0A024RAP8
    Conserved Domains (2) summary
    cd03593
    Location:99213
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    PHA03097
    Location:47214
    PHA03097; C-type lectin-like protein; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    10372353..10410146 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center