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MROH7-TTC4 MROH7-TTC4 readthrough (NMD candidate) [ Homo sapiens (human) ]

Gene ID: 100527960, updated on 13-May-2022

Summary

Official Symbol
MROH7-TTC4provided by HGNC
Official Full Name
MROH7-TTC4 readthrough (NMD candidate)provided by HGNC
Primary source
HGNC:HGNC:49180
See related
Ensembl:ENSG00000271723 AllianceGenome:HGNC:49180
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MROH7; HEATR8; C1orf175; HEATR8-TTC4
Summary
This locus represents naturally occurring read-through transcription between the neighboring MROH7 (maestro heat-like repeat family member 7) and TTC4 (tetratricopeptide repeat domain 4) genes. Alternative splicing results in multiple transcript variants, which are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to produce protein products. [provided by RefSeq, Aug 2013]
Expression
Broad expression in testis (RPKM 32.6), ovary (RPKM 4.1) and 22 other tissues See more
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Genomic context

See MROH7-TTC4 in Genome Data Viewer
Location:
1p32.3
Exon count:
34
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (54641740..54742657)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (54521968..54622890)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (55107413..55208330)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 63 Neighboring gene acyl-CoA thioesterase 11 Neighboring gene family with sequence similarity 151 member A Neighboring gene maestro heat like repeat family member 7 Neighboring gene tetratricopeptide repeat domain 4 Neighboring gene prolyl-tRNA synthetase 2, mitochondrial Neighboring gene uncharacterized LOC124904182 Neighboring gene Sharpr-MPRA regulatory region 10932 Neighboring gene tetratricopeptide repeat domain 22

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
A genome-wide association study of behavioral disinhibition.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough MROH7-TTC4

Included genes: TTC4, MROH7

Other Names

  • HEAT repeat-containing protein 8
  • HEATR8-TTC4 readthrough
  • Maestro heat-like repeat-containing protein family member 7

Clone Names

  • FLJ20619, FLJ45063, FLJ46354, DKFZp686L2332, DKFZp781B0622

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_037639.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AL139244, AL590093, BC028620, BX648088, CR749830
    Related
    ENST00000425300.6
  2. NR_037640.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon and uses two alternate splice sites in the 5' region, and includes an additional exon in the central region, compared to variant 1.
    Source sequence(s)
    AL139244, AL590093, BX648088
    Related
    ENST00000414150.6
  3. NR_037641.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site and lacks an alternate exon in the 5' region, uses an alternate splice site and lacks an alternate exon but includes a different alternate exon in the central region, and lacks an alternate segment in the 3' region, compared to variant 1.
    Source sequence(s)
    AL139244, AL590093, BC028620
    Related
    ENST00000606515.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    54641740..54742657
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    54521968..54622890
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)