Format

Send to:

Choose Destination

RBM14-RBM4 RBM14-RBM4 readthrough [ Homo sapiens (human) ]

Gene ID: 100526737, updated on 23-Nov-2021

Summary

Official Symbol
RBM14-RBM4provided by HGNC
Official Full Name
RBM14-RBM4 readthroughprovided by HGNC
Primary source
HGNC:HGNC:38840
See related
Ensembl:ENSG00000248643
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIP; COAZ; PSP2; RBM14
Summary
This locus represents naturally occurring read-through transcription between the neighboring RBM14 (RNA binding motif protein 14) and RBM4 (RNA binding motif protein 4) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with each individual gene product. This fusion protein contains RRM and zinc finger domains, and it functions to stimulate transcription in a hormone and receptor-dependent manner. [provided by RefSeq, Nov 2010]
Expression
Ubiquitous expression in testis (RPKM 23.5), bone marrow (RPKM 21.4) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See RBM14-RBM4 in Genome Data Viewer
Location:
11q13.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (66616630..66646468)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (66384101..66413939)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene copper chaperone for superoxide dismutase Neighboring gene RNA, U4 small nuclear 39, pseudogene Neighboring gene RNA binding motif protein 14 Neighboring gene RNA binding motif protein 4 Neighboring gene RNA binding motif protein 4B Neighboring gene spectrin beta, non-erythrocytic 2 Neighboring gene RNA, 7SL, cytoplasmic 12, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough RBM14-RBM4

Included genes: RBM4, RBM14

Homology

Clone Names

  • FLJ78260

General protein information

Preferred Names
RBM14-RBM4 protein
Names
Paraspeckle protein 2
RBM14/RBM4 fusion
RNA-binding motif protein 14
RNA-binding protein 14
RRM-containing coactivator activator/modulator
SYT-interacting protein
Synaptotagmin-interacting protein
transcriptional coactivator CoAZ

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198845.2NP_001185774.1  RBM14-RBM4 protein isoform 1

    See identical proteins and their annotated locations for NP_001185774.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1), which shares sequence identity with the products of both the RBM14 and RBM4 genes.
    Source sequence(s)
    EU287938
    Consensus CDS
    CCDS55774.1
    UniProtKB/Swiss-Prot
    Q96PK6
    Related
    ENSP00000388552.2, ENST00000412278.2
    Conserved Domains (3) summary
    smart00343
    Location:136151
    ZnF_C2HC; zinc finger
    cd12608
    Location:171
    RRM1_CoAA; RNA recognition motif 1 in vertebrate RRM-containing coactivator activator/modulator (CoAA)
    cl17169
    Location:79113
    RRM_SF; RNA recognition motif (RRM) superfamily
  2. NM_001198846.2NP_001185775.1  RBM14-RBM4 protein isoform 2

    See identical proteins and their annotated locations for NP_001185775.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AP001157, AW958943
    UniProtKB/TrEMBL
    A0A0A6YYI9
    Related
    ENSP00000421279.1, ENST00000500635.2
    Conserved Domains (1) summary
    cl17169
    Location:171
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    66616630..66646468
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center