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aldh1l1 aldehyde dehydrogenase 1 family, member L1 [ Danio rerio (zebrafish) ]

Gene ID: 100526683, updated on 19-Nov-2025
Official Symbol
aldh1l1provided by ZNC
Official Full Name
aldehyde dehydrogenase 1 family, member L1provided by ZNC
Primary source
ZFIN:ZDB-GENE-100519-4
See related
Ensembl:ENSDARG00000077004 AllianceGenome:ZFIN:ZDB-GENE-100519-4
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Enables formyltetrahydrofolate dehydrogenase activity and hydrolase activity. Acts upstream of or within several processes, including embryonic morphogenesis; neural crest cell migration; and neuromast deposition. Predicted to be located in cytosol. Is expressed in several structures, including cardiovascular system; digestive system; fin; hematopoietic system; and nervous system. Orthologous to human ALDH1L1 (aldehyde dehydrogenase 1 family member L1). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See aldh1l1 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 6 NC_133181.1 (20508347..20540978)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 6 NC_007117.7 (22069100..22101812)

Chromosome 6 - NC_133181.1Genomic Context describing neighboring genes Neighboring gene THUMP domain containing 3 Neighboring gene si:dkey-156n14.3 Neighboring gene cilia and flagella associated protein 100 Neighboring gene DEAD-box helicase 17 Neighboring gene golgi-associated, gamma adaptin ear containing, ARF binding protein 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Zebrafish 10-formyltetrahydrofolate dehydrogenase is similar to its mammalian isozymes for its structural and catalytic properties. Chang WN, et al. Protein Expr Purif, 2010 Aug. PMID 20381623
  2. Structures of the hydrolase domain of zebrafish 10-formyltetrahydrofolate dehydrogenase and its complexes reveal a complete set of key residues for hydrolysis and product inhibition. Lin CC, et al. Acta Crystallogr D Biol Crystallogr, 2015 Apr. PMID 25849409, Free PMC Article
  3. Aldehyde dehydrogenase homologous folate enzymes: Evolutionary switch between cytoplasmic and mitochondrial localization. Krupenko NI, et al. Chem Biol Interact, 2015 Jun 5. PMID 25549576, Free PMC Article
  4. Ethanol-induced upregulation of 10-formyltetrahydrofolate dehydrogenase helps relieve ethanol-induced oxidative stress. Hsiao TH, et al. Mol Cell Biol, 2014 Feb. PMID 24277932, Free PMC Article
  5. Folate deprivation induced neuroinflammation impairs cognition. Shaikh A, et al. Neurosci Lett, 2023 Jun 11. PMID 37086862

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The crystal structures of apo-form N-terminal domain - FDH and its complexes with the substrate analogue 10-formyl-5,8-dideazafolate (10-FDDF) and with the products tetrahydrofolate and formate have been determined.
    Title: Structures of the hydrolase domain of zebrafish 10-formyltetrahydrofolate dehydrogenase and its complexes reveal a complete set of key residues for hydrolysis and product inhibition.
  2. Knock-down of the fdh(10-Formyltetrahydrofolate dehydrogenase) gene impeded morphogenetic movement and caused incorrect cardiac positioning, defective hematopoiesis, notochord malformation and ultimate death of morphants
    Title: Knocking down 10-Formyltetrahydrofolate dehydrogenase increased oxidative stress and impeded zebrafish embryogenesis by obstructing morphogenetic movement.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables aldehyde dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables formyltetrahydrofolate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables formyltetrahydrofolate dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables formyltetrahydrofolate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 10-formyltetrahydrofolate catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within embryonic viscerocranium morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within gastrulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neural crest cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuromast deposition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in one-carbon metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
cytosolic 10-formyltetrahydrofolate dehydrogenase
Names
10-formyltetrahydrofolate dehydrogenase
FDH
NP_001185701.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198772.1 → NP_001185701.1  cytosolic 10-formyltetrahydrofolate dehydrogenase

    See identical proteins and their annotated locations for NP_001185701.1

    Status: PROVISIONAL

    Source sequence(s)
    EU686693
    UniProtKB/TrEMBL
    E3NZ06
    Related
    ENSDARP00000126310.1, ENSDART00000151205.3
    Conserved Domains (4) summary
    cd07140
    Location:418 → 903
    ALDH_F1L_FTFDH; 10-formyltetrahydrofolate dehydrogenase, ALDH family 1L
    cd08647
    Location:1 → 203
    FMT_core_FDH_N; 10-formyltetrahydrofolate dehydrogenase (FDH), N-terminal hydrolase domain
    cd08703
    Location:206 → 307
    FDH_Hydrolase_C; The C-terminal subdomain of the hydrolase domain on the bi-functional protein 10-formyltetrahydrofolate dehydrogenase
    COG0223
    Location:1 → 306
    Fmt; Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133181.1 Reference GRCz12tu Primary Assembly

    Range
    20508347..20540978
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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