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PRKCE protein kinase C epsilon [ Sus scrofa (pig) ]

Gene ID: 100524932, updated on 8-Mar-2024

Summary

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Official Symbol
PRKCEprovided by VGNC
Official Full Name
protein kinase C epsilonprovided by VGNC
Primary source
VGNC:VGNC:91807
See related
Ensembl:ENSSSCG00000008444
Gene type
protein coding
RefSeq status
MODEL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Ubiquitous expression in kidney (RPKM 8.0), lung (RPKM 5.3) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See PRKCE in Genome Data Viewer
Location:
chromosome: 3
Exon count:
19
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 3 NC_010445.4 (94351277..94864549, complement)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 3 NC_010445.3 (100427723..100762372, complement)

Chromosome 3 - NC_010445.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110260021 Neighboring gene uncharacterized LOC106509830 Neighboring gene endothelial PAS domain protein 1 Neighboring gene uncharacterized LOC110260103 Neighboring gene nuclear transport factor 2 pseudogene Neighboring gene S1 RNA binding domain 1 Neighboring gene uncharacterized LOC106509837

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Endothelin-1 promotes Ca2+ antagonist-insensitive coronary smooth muscle contraction via activation of epsilon-protein kinase C. McNair LL, et al. Hypertension, 2004 Apr. PMID 14981072

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A significant component of ET-1-induced contraction of coronary smooth muscle is Ca2+ antagonist-insensitive, involving activation & translocation of Ca2+-independent epsilon-PKC.
    Title: Endothelin-1 promotes Ca2+ antagonist-insensitive coronary smooth muscle contraction via activation of epsilon-protein kinase C.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
protein kinase C epsilon type

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010445.4 Reference Sscrofa11.1 Primary Assembly

    Range
    94351277..94864549 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021088295.1 → XP_020943954.1  protein kinase C epsilon type isoform X1

    UniProtKB/TrEMBL
    A0A8D0II66, F1S5K7
    Related
    ENSSSCP00000009012.3, ENSSSCT00000009246.5
    Conserved Domains (3) summary
    cd04014
    Location:3 → 135
    C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
    cd05591
    Location:412 → 732
    STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
    pfam00130
    Location:243 → 295
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  2. XM_021088294.1 → XP_020943953.1  protein kinase C epsilon type isoform X1

    UniProtKB/TrEMBL
    A0A8D0II66, F1S5K7
    Conserved Domains (3) summary
    cd04014
    Location:3 → 135
    C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
    cd05591
    Location:412 → 732
    STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
    pfam00130
    Location:243 → 295
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  3. XM_021088296.1 → XP_020943955.1  protein kinase C epsilon type isoform X2

    UniProtKB/TrEMBL
    A0A287AHR4, A0A4X1SI02
    Related
    ENSSSCP00000043432.1, ENSSSCT00000059011.2
    Conserved Domains (2) summary
    cd05591
    Location:407 → 727
    STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
    pfam00130
    Location:238 → 290
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  4. XM_021088297.1 → XP_020943956.1  protein kinase C epsilon type isoform X3

    UniProtKB/TrEMBL
    A0A4X1SI40
    Conserved Domains (3) summary
    cd04014
    Location:3 → 135
    C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
    pfam00130
    Location:243 → 295
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl21453
    Location:412 → 689
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
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