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RNF212B ring finger protein 212B [ Homo sapiens (human) ]

Gene ID: 100507650, updated on 26-Oct-2022

Summary

Official Symbol
RNF212Bprovided by HGNC
Official Full Name
ring finger protein 212Bprovided by HGNC
Primary source
HGNC:HGNC:20438
See related
Ensembl:ENSG00000215277 AllianceGenome:HGNC:20438
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C14orf164
Summary
Predicted to enable SUMO transferase activity. Predicted to be involved in homologous chromosome pairing at meiosis and protein sumoylation. Predicted to be active in synaptonemal complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney (RPKM 3.6), testis (RPKM 2.0) and 20 other tissues See more
Orthologs
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Genomic context

See RNF212B in Genome Data Viewer
Location:
14q11.2
Exon count:
17
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (23185336..23273477)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (17386004..17474456)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (23654545..23742686)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene CCAAT enhancer binding protein epsilon Neighboring gene solute carrier family 7 member 8 Neighboring gene RNA, U6 small nuclear 1138, pseudogene Neighboring gene uncharacterized LOC105370406 Neighboring gene ribosomal protein L39 pseudogene 2 Neighboring gene RNA, U6 small nuclear 1046, pseudogene Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 1 Neighboring gene homeobox and leucine zipper encoding Neighboring gene BCL2L2-PABPN1 readthrough Neighboring gene protein phosphatase 1 regulatory subunit 3E Neighboring gene H3 histone pseudogene 37 Neighboring gene BCL2 like 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SUMO transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in homologous chromosome pairing at meiosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in reciprocal meiotic recombination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in synaptonemal complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
RING finger protein 212B
Names
RING finger protein C14orf164-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282322.3NP_001269251.1  RING finger protein 212B

    See identical proteins and their annotated locations for NP_001269251.1

    Status: VALIDATED

    Source sequence(s)
    AL049829
    Consensus CDS
    CCDS61401.1
    UniProtKB/Swiss-Prot
    A8MTL3
    Related
    ENSP00000397830.2, ENST00000430154.7
    Conserved Domains (1) summary
    cd16747
    Location:540
    RING-HC_RNF212B; RING finger, HC subclass, found in RING finger protein 212B (RNF212B) and similar proteins
  2. NM_001370218.3NP_001357147.1  RING finger protein 212B

    Status: VALIDATED

    Source sequence(s)
    AL049829, AL117258
    Consensus CDS
    CCDS61401.1
    UniProtKB/Swiss-Prot
    A8MTL3
    Related
    ENSP00000382794.1, ENST00000399910.5
    Conserved Domains (1) summary
    cd16747
    Location:540
    RING-HC_RNF212B; RING finger, HC subclass, found in RING finger protein 212B (RNF212B) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    23185336..23273477
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536323.3XP_011534625.1  RING finger protein 212B isoform X3

    Conserved Domains (2) summary
    pfam14634
    Location:541
    zf-RING_5; zinc-RING finger domain
    cl01090
    Location:94151
    SlyX; SlyX
  2. XM_011536316.3XP_011534618.1  RING finger protein 212B isoform X1

    Conserved Domains (2) summary
    pfam14634
    Location:541
    zf-RING_5; zinc-RING finger domain
    cl01090
    Location:94151
    SlyX; SlyX
  3. XM_011536327.3XP_011534629.1  RING finger protein 212B isoform X4

    Conserved Domains (1) summary
    pfam14634
    Location:541
    zf-RING_5; zinc-RING finger domain
  4. XM_011536328.3XP_011534630.1  RING finger protein 212B isoform X5

  5. XM_011536319.3XP_011534621.1  RING finger protein 212B isoform X2

    See identical proteins and their annotated locations for XP_011534621.1

    Conserved Domains (1) summary
    pfam05600
    Location:2498
    DUF773; Protein of unknown function (DUF773)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    17386004..17474456
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)