LINC00968 long intergenic non-protein coding RNA 968 [Homo sapiens (human)] - Gene

Summary

Official Symbol: LINC00968provided by HGNC
Official Full Name: long intergenic non-protein coding RNA 968provided by HGNC
Primary source: HGNC:HGNC:48727
See related: Ensembl:ENSG00000246430 AllianceGenome:HGNC:48727
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression: Biased expression in lung (RPKM 3.9), placenta (RPKM 1.1) and 8 other tissues See more
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Genomic context

Location:: 8q12.1

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (56518318..56559823, complement)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (56895557..56937083, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (57430877..57472382, complement)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LINC00968 promotes osteogenic differentiation in vitro and bone formation in vivo via regulation of miR-3658/RUNX2.
Title: LINC00968 promotes osteogenic differentiation in vitro and bone formation in vivo via regulation of miR-3658/RUNX2.
LINC00968 can inhibit the progression of lung adenocarcinoma through the miR-21-5p/SMAD7 signal axis.
Title: LINC00968 can inhibit the progression of lung adenocarcinoma through the miR-21-5p/SMAD7 signal axis.
LINC00968 accelerates the progression of epithelial ovarian cancer via mediating the cell cycle progression.
Title: LINC00968 accelerates the progression of epithelial ovarian cancer via mediating the cell cycle progression.
in our study, we found that PI3K/AKT/mTOR pathway was involved in osteosarcoma progression. Knockdown of LINC00968 inactivated PI3K/AKT/mTOR signaling pathway in vitro. Subsequently, in vivo tumor xenografts were established using 143-B cells to investigate whether LINC00968 can induce osteosarcoma development in vivo
Title: LINC00968 functions as an oncogene in osteosarcoma by activating the PI3K/AKT/mTOR signaling.
a prospective lncRNAmiRNA-mRNA regulatory network of LINC00968, three miRNAs (miR-9, miR-22 and miR-4536) and two genes (polo-like kinase 1 and exportin-1) was obtained following validation in the Cancer Genome Atlas database. These results may provide novel insights to support future research into lncRNA in lung cancer.
Title: Prospective lncRNA-miRNA-mRNA regulatory network of long non-coding RNA LINC00968 in non-small cell lung cancer A549 cells: A miRNA microarray and bioinformatics investigation.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

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General gene information

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Markers

RH92188 (e-PCR)
- UniSTS:84269

D8S1661 (e-PCR)
- UniSTS:67925

SHGC-77990 (e-PCR)
- UniSTS:101536

D8S444 (e-PCR)
- UniSTS:696

D8S166 (e-PCR), detects polymorphism
- UniSTS:146886

RH12491 (e-PCR)
- UniSTS:11219

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.