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TGFBR3L transforming growth factor beta receptor 3 like [ Homo sapiens (human) ]

Gene ID: 100507588, updated on 23-Nov-2023

Summary

Official Symbol
TGFBR3Lprovided by HGNC
Official Full Name
transforming growth factor beta receptor 3 likeprovided by HGNC
Primary source
HGNC:HGNC:44152
See related
Ensembl:ENSG00000260001 AllianceGenome:HGNC:44152
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GEMP; TGFR-3L
Summary
Predicted to enable glycosaminoglycan binding activity; transforming growth factor beta-activated receptor activity; and type II transforming growth factor beta receptor binding activity. Predicted to contribute to transforming growth factor beta binding activity. Predicted to be involved in several processes, including blood vessel morphogenesis; regulation of transforming growth factor beta receptor signaling pathway; and transforming growth factor beta receptor signaling pathway. Predicted to be integral component of membrane. Predicted to be active in cell surface and extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney (RPKM 1.1), brain (RPKM 1.1) and 11 other tissues See more
Orthologs
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Genomic context

See TGFBR3L in Genome Data Viewer
Location:
19p13.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (7914830..7919097)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (7915785..7920052)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (7979715..7983982)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 8 VRAC subunit E Neighboring gene uncharacterized LOC124904630 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:7968039-7968616 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:7969265-7969804 Neighboring gene mitogen-activated protein kinase kinase 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:7980702-7981202 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9996 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:7981823-7982699 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:7982700-7983575 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:7984251-7984750 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10000 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10001 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:7986451-7987053 Neighboring gene small nuclear RNA activating complex polypeptide 2 Neighboring gene uncharacterized LOC124904629 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10002 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10003 Neighboring gene cortexin 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables glycosaminoglycan binding IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to transforming growth factor beta binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transforming growth factor beta receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables type II transforming growth factor beta receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in epithelial to mesenchymal transition IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transforming growth factor-beta receptor type 3-like protein
Names
TGF-beta receptor type III-like protein
TGF-beta receptor type-3-like protein
gonadotroph enriched membrane protein
transforming growth factor, beta receptor III-like
transforming growth factor-beta receptor type III-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195259.2NP_001182188.1  transforming growth factor-beta receptor type 3-like protein isoform 2

    See identical proteins and their annotated locations for NP_001182188.1

    Status: VALIDATED

    Source sequence(s)
    AC010336
    Consensus CDS
    CCDS58648.1
    UniProtKB/Swiss-Prot
    H3BV60
    Related
    ENSP00000457962.1, ENST00000565886.2
    Conserved Domains (1) summary
    pfam00100
    Location:75174
    Zona_pellucida; Zona pellucida-like domain
  2. NM_001419781.1NP_001406710.1  transforming growth factor-beta receptor type 3-like protein isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC010336
    UniProtKB/Swiss-Prot
    H3BV60

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    7914830..7919097
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527610.3XP_011525912.1  transforming growth factor-beta receptor type 3-like protein isoform X1

    Conserved Domains (1) summary
    pfam00100
    Location:120200
    Zona_pellucida; Zona pellucida-like domain
  2. XM_011527613.3XP_011525915.1  transforming growth factor-beta receptor type 3-like protein isoform X2

    See identical proteins and their annotated locations for XP_011525915.1

    Conserved Domains (1) summary
    pfam00100
    Location:120200
    Zona_pellucida; Zona pellucida-like domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    7915785..7920052
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319480.1XP_054175455.1  transforming growth factor-beta receptor type 3-like protein isoform X1

  2. XM_054319481.1XP_054175456.1  transforming growth factor-beta receptor type 3-like protein isoform X2