U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

STRIT1 small transmembrane regulator of ion transport 1 [ Homo sapiens (human) ]

Gene ID: 100507537, updated on 22-Sep-2022

Summary

Official Symbol
STRIT1provided by HGNC
Official Full Name
small transmembrane regulator of ion transport 1provided by HGNC
Primary source
HGNC:HGNC:52297
See related
Ensembl:ENSG00000240045 MIM:616891; AllianceGenome:HGNC:52297
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DWORF
Summary
Predicted to enable enzyme activator activity. Predicted to be involved in regulation of calcium ion transport and regulation of striated muscle contraction. Predicted to act upstream of or within positive regulation of ATPase-coupled calcium transmembrane transporter activity and positive regulation of calcium ion import. Predicted to be located in sarcoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in prostate (RPKM 12.1), esophagus (RPKM 5.3) and 4 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See STRIT1 in Genome Data Viewer
Location:
3q25.2
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (155290227..155293683, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (158064207..158067663, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (155008016..155011472, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene membrane metalloendopeptidase Neighboring gene Sharpr-MPRA regulatory region 4432 Neighboring gene long intergenic non-protein coding RNA 1487 Neighboring gene uncharacterized LOC105374172 Neighboring gene poly(A) binding protein cytoplasmic 1 pseudogene 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables enzyme activator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in positive regulation of calcium ion import into sarcoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of ATPase-coupled calcium transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of slow-twitch skeletal muscle fiber contraction ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in sarcoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF
Names
SERCA regulator DWORF
Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001352129.2NP_001339058.1  sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF

    Status: VALIDATED

    Source sequence(s)
    AC104831, BC015836
    Consensus CDS
    CCDS87158.1
    UniProtKB/Swiss-Prot
    A0A1B0GTW0
    Related
    ENSP00000489859.1, ENST00000489090.2
    Conserved Domains (1) summary
    cd20247
    Location:135
    DWORF; DWarf Open Reading Frame (DWORF)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    155290227..155293683 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    158064207..158067663 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)