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TMEM178B transmembrane protein 178B [ Homo sapiens (human) ]

Gene ID: 100507421, updated on 22-Sep-2022

Summary

Official Symbol
TMEM178Bprovided by HGNC
Official Full Name
transmembrane protein 178Bprovided by HGNC
Primary source
HGNC:HGNC:44112
See related
Ensembl:ENSG00000261115 AllianceGenome:HGNC:44112
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be integral component of membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 6.9), thyroid (RPKM 5.0) and 9 other tissues See more
Orthologs
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Genomic context

See TMEM178B in Genome Data Viewer
Location:
7q34
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (141074064..141511296)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (142388269..142796130)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (140773864..141180180)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986719 Neighboring gene uncharacterized LOC105375537 Neighboring gene uncharacterized LOC124901760 Neighboring gene NADH:ubiquinone oxidoreductase subunit B10 pseudogene 2 Neighboring gene AGK divergent transcript Neighboring gene acylglycerol kinase Neighboring gene DENN domain containing 11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ39162, FLJ42883, DKFZp547G036

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195278.2NP_001182207.1  transmembrane protein 178B precursor

    See identical proteins and their annotated locations for NP_001182207.1

    Status: VALIDATED

    Source sequence(s)
    AC005692, AC006362, AC006396, AC073878
    Consensus CDS
    CCDS59086.1
    UniProtKB/Swiss-Prot
    H3BS89
    Related
    ENSP00000456594.1, ENST00000565468.6
    Conserved Domains (1) summary
    cl21598
    Location:100266
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    141074064..141511296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011636.2XP_016867125.1  transmembrane protein 178B isoform X2

  2. XM_011515705.3XP_011514007.1  transmembrane protein 178B isoform X1

    Conserved Domains (1) summary
    cl21598
    Location:104218
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RNA

  1. XR_001744505.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    142388269..142796130
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)