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SMIM18 small integral membrane protein 18 [ Homo sapiens (human) ]

Gene ID: 100507341, updated on 5-Jan-2022

Summary

Official Symbol
SMIM18provided by HGNC
Official Full Name
small integral membrane protein 18provided by HGNC
Primary source
HGNC:HGNC:42973
See related
Ensembl:ENSG00000253457
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in brain (RPKM 1.9), adrenal (RPKM 0.3) and 1 other tissue See more
Orthologs
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Genomic context

See SMIM18 in Genome Data Viewer
Location:
8p12
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (30637771..30646064)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (30496097..30503581)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene RNA binding protein, mRNA processing factor Neighboring gene Sharpr-MPRA regulatory region 2547 Neighboring gene uncharacterized LOC112268024 Neighboring gene general transcription factor IIE subunit 2 Neighboring gene RNA, U5A small nuclear 3, pseudogene Neighboring gene glutathione-disulfide reductase Neighboring gene uncharacterized LOC105379356 Neighboring gene uncharacterized LOC105379355 Neighboring gene UBX domain protein 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
small integral membrane protein 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001206847.2NP_001193776.1  small integral membrane protein 18

    See identical proteins and their annotated locations for NP_001193776.1

    Status: VALIDATED

    Source sequence(s)
    AC102945, AC103959, BM710955, DR033682
    Consensus CDS
    CCDS56529.1
    UniProtKB/Swiss-Prot
    P0DKX4
    Related
    ENSP00000428858.1, ENST00000517349.2
    Conserved Domains (1) summary
    cd20255
    Location:485
    CASIMO1_SMIM22; small integral membrane protein 22 (SMIM22) of CASIMO1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    30637771..30646064
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012943.1XP_016868432.1  small integral membrane protein 18 isoform X1

    UniProtKB/Swiss-Prot
    P0DKX4
    Conserved Domains (1) summary
    cd20255
    Location:485
    CASIMO1_SMIM22; small integral membrane protein 22 (SMIM22) of CASIMO1
  2. XM_024447050.1XP_024302818.1  small integral membrane protein 18 isoform X1

    Conserved Domains (1) summary
    cd20255
    Location:485
    CASIMO1_SMIM22; small integral membrane protein 22 (SMIM22) of CASIMO1
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