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LRCOL1 leucine rich colipase like 1 [ Homo sapiens (human) ]

Gene ID: 100507055, updated on 7-Apr-2025

Summary

Official Symbol
LRCOL1provided by HGNC
Official Full Name
leucine rich colipase like 1provided by HGNC
Primary source
HGNC:HGNC:44160
See related
Ensembl:ENSG00000204583 AllianceGenome:HGNC:44160
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable enzyme activator activity. Predicted to be involved in digestion and lipid catabolic process. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in liver (RPKM 1.8), lung (RPKM 0.7) and 10 other tissues See more
Orthologs
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Genomic context

See LRCOL1 in Genome Data Viewer
Location:
12q24.33
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (132603151..132610582, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (132653401..132660802, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (133179737..133187168, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903062 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7385 Neighboring gene uncharacterized LOC105370094 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:133177517-133178052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:133178053-133178587 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:133180217-133180843 Neighboring gene purinergic receptor P2X 2 Neighboring gene DNA polymerase epsilon, catalytic subunit Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5123

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables enzyme activator activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in digestion IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
leucine-rich colipase-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195520.2NP_001182449.1  leucine-rich colipase-like protein 1 precursor

    See identical proteins and their annotated locations for NP_001182449.1

    Status: VALIDATED

    Source sequence(s)
    AC131212, AV653338, BX282338, DB344052
    Consensus CDS
    CCDS73547.1
    UniProtKB/Swiss-Prot
    A6NCL2, H9BFB1
    Related
    ENSP00000479730.1, ENST00000376608.9
    Conserved Domains (1) summary
    pfam15083
    Location:66153
    Colipase-like; Colipase-like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    132603151..132610582 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534780.3XP_011533082.1  leucine-rich colipase-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011533082.1

    Conserved Domains (1) summary
    pfam15083
    Location:66153
    Colipase-like; Colipase-like
  2. XM_047428045.1XP_047284001.1  leucine-rich colipase-like protein 1 isoform X2

  3. XM_011534784.2XP_011533086.1  leucine-rich colipase-like protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011533086.1

    Conserved Domains (1) summary
    pfam15083
    Location:25101
    Colipase-like
  4. XM_011534785.2XP_011533087.1  leucine-rich colipase-like protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011533087.1

    Conserved Domains (1) summary
    pfam15083
    Location:25101
    Colipase-like
  5. XM_047428046.1XP_047284002.1  leucine-rich colipase-like protein 1 isoform X3

  6. XM_047428044.1XP_047284000.1  leucine-rich colipase-like protein 1 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    132653401..132660802 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054370709.1XP_054226684.1  leucine-rich colipase-like protein 1 isoform X1

  2. XM_054370711.1XP_054226686.1  leucine-rich colipase-like protein 1 isoform X2

  3. XM_054370713.1XP_054226688.1  leucine-rich colipase-like protein 1 isoform X2

  4. XM_054370712.1XP_054226687.1  leucine-rich colipase-like protein 1 isoform X2

  5. XM_054370714.1XP_054226689.1  leucine-rich colipase-like protein 1 isoform X3

  6. XM_054370710.1XP_054226685.1  leucine-rich colipase-like protein 1 isoform X2