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TPBGL trophoblast glycoprotein like [ Homo sapiens (human) ]

Gene ID: 100507050, updated on 22-Sep-2022

Summary

Official Symbol
TPBGLprovided by HGNC
Official Full Name
trophoblast glycoprotein likeprovided by HGNC
Primary source
HGNC:HGNC:44159
See related
Ensembl:ENSG00000261594 AllianceGenome:HGNC:44159
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See TPBGL in Genome Data Viewer
Location:
11q13.4
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (75240774..75243704)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (75170381..75173311)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (74951819..74954749)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902717 Neighboring gene zinc finger DHHC-type containing 20 pseudogene 3 Neighboring gene arrestin beta 1 Neighboring gene microRNA 326 Neighboring gene small nucleolar RNA, C/D box 15A Neighboring gene ribosomal protein S3

Genomic regions, transcripts, and products

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
trophoblast glycoprotein-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195528.2NP_001182457.1  trophoblast glycoprotein-like precursor

    See identical proteins and their annotated locations for NP_001182457.1

    Status: VALIDATED

    Source sequence(s)
    AP001972, BC007804, N54218
    Consensus CDS
    CCDS60895.1
    UniProtKB/Swiss-Prot
    P0DKB5
    Related
    ENSP00000474988.1, ENST00000562197.3
    Conserved Domains (3) summary
    sd00031
    Location:6195
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:94151
    LRR_8; Leucine rich repeat
    cl15307
    Location:234267
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    75240774..75243704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    75170381..75173311
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)