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TUNAR transmembrane neural differentiation associated intracellular calcium regulator [ Homo sapiens (human) ]

Gene ID: 100507043, updated on 6-Jul-2026
Official Symbol
TUNARprovided by HGNC
Official Full Name
transmembrane neural differentiation associated intracellular calcium regulatorprovided by HGNC
Primary source
HGNC:HGNC:44088
See related
Ensembl:ENSG00000250366 MIM:615719; AllianceGenome:HGNC:44088
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BNLN; TUNA; pTUNAR; HI-LNC78; LINC00617
Summary
Enables ATPase binding activity. Involved in endoplasmic reticulum calcium ion homeostasis and positive regulation of insulin secretion involved in cellular response to glucose stimulus. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in endometrium (RPKM 5.7), brain (RPKM 3.3) and 3 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See TUNAR in Genome Data Viewer
Location:
14q32.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (95876448..95925571)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (90107959..90157077)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (96342785..96391908)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984703 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8977 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8978 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8979 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8980 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:96237254-96237437 Neighboring gene uncharacterized LOC105370644 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:96352667-96353446 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:96357499-96358698 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96366753-96367253 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:96370580-96371523 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:96373730-96374416 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96375462-96375984 Neighboring gene MPRA-validated peak2244 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:96413280-96414129 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr14:96414130-96414978 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr14:96414979-96415828 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr14:96434413-96434986 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:96441645-96442145 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr14:96444767-96445284 Neighboring gene NANOG hESC enhancer GRCh37_chr14:96445987-96446488 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:96458745-96459302 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr14:96459861-96460418 and GRCh37_chr14:96460419-96460976 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96467893-96468394 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6051 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6052 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8981 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96519945-96520444 Neighboring gene chromosome 14 open reading frame 132 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:96526720-96526873 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:96529045-96529222 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8982 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:96552361-96553560 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_38841 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96560846-96561346 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96561347-96561847 Neighboring gene uncharacterized LOC124903374 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96563297-96563798

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. The long noncoding RNA TUNAR modulates Wnt signaling and regulates human β-cell proliferation. Zhou AX, et al. Am J Physiol Endocrinol Metab, 2021 Apr 1. PMID 33682459
  2. Long noncoding RNA linc00617 exhibits oncogenic activity in breast cancer. Li H, et al. Mol Carcinog, 2017 Jan. PMID 26207516
  3. A putative long noncoding RNA-encoded micropeptide maintains cellular homeostasis in pancreatic β cells. Li M, et al. Mol Ther Nucleic Acids, 2021 Dec 3. PMID 34513312, Free PMC Article
  4. TUNAR lncRNA Encodes a Microprotein that Regulates Neural Differentiation and Neurite Formation by Modulating Calcium Dynamics. Senís E, et al. Front Cell Dev Biol, 2021. PMID 35036403, Free PMC Article
  5. An evolutionarily conserved long noncoding RNA TUNA controls pluripotency and neural lineage commitment. Lin N, et al. Mol Cell, 2014 Mar 20. PMID 24530304, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The long noncoding RNA TUNAR modulates Wnt signaling and regulates human beta-cell proliferation.
    Title: The long noncoding RNA TUNAR modulates Wnt signaling and regulates human β-cell proliferation.
  2. This study found the human ortholog of TUNA, linc00617, was upregulated in breast cancer samples.
    Title: Long noncoding RNA linc00617 exhibits oncogenic activity in breast cancer.
Submit: New GeneRIF Correction

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ATPase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum calcium ion homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neuron projection morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cytosolic calcium ion concentration ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane EXP
Inferred from Experiment
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
protein TUNAR
Names
Human Islet Long Non Coding RNA 78
TCL1 upstream neural differentiation-associated RNA
TUNAR lncRNA
Tcl1 upstream neuron-associated lincRNA
beta cell- and neural cell-regulin
long intergenic non-protein coding RNA 617

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001416131.1 → NP_001403060.1  protein TUNAR isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL133167
    UniProtKB/TrEMBL
    A0A7I2V4K3
    Related
    ENSP00000489624.3, ENST00000503525.3

  2. NM_001416132.1 → NP_001403061.1  protein TUNAR isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL133167
    UniProtKB/Swiss-Prot
    A0A1B0GTB2, A0A1B0GUV0
    Related
    ENSP00000490254.2, ENST00000554321.2

  3. NM_001416133.1 → NP_001403062.1  protein TUNAR isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL133167
    UniProtKB/Swiss-Prot
    A0A1B0GTB2, A0A1B0GUV0
    Related
    ENSP00000498192.1, ENST00000504119.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    95876448..95925571
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    90107959..90157077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_038861.1: Suppressed sequence

    Description
    NR_038861.1: This RefSeq was removed because it is now thought that this gene does encode a protein.

  2. NR_132398.1: Suppressed sequence

    Description
    NR_132398.1: This RefSeq was removed because it is now thought that this gene does encode a protein.

  3. NR_132399.1: Suppressed sequence

    Description
    NR_132399.1: This RefSeq was removed because it is now thought that this gene does encode a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A1B0GTB2.2 GenPept UniProtKB/Swiss-Prot:A0A1B0GTB2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials