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TUNAR TCL1 upstream neural differentiation-associated RNA [ Homo sapiens (human) ]

Gene ID: 100507043, updated on 29-Mar-2023

Summary

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Official Symbol
TUNARprovided by HGNC
Official Full Name
TCL1 upstream neural differentiation-associated RNAprovided by HGNC
Primary source
HGNC:HGNC:44088
See related
Ensembl:ENSG00000250366 MIM:615719; AllianceGenome:HGNC:44088
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BNLN; TUNA; pTUNAR; HI-LNC78; LINC00617
Summary
Predicted to act upstream of or within several processes, including positive regulation of chromatin binding activity; positive regulation of mitotic cell cycle; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Predicted to be part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in endometrium (RPKM 5.7), brain (RPKM 3.3) and 3 other tissues See more
Orthologs
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Genomic context

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See TUNAR in Genome Data Viewer
Location:
14q32.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (95876448..95925571)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (90107959..90157077)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (96342729..96391908)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984703 Neighboring gene uncharacterized LOC105370644 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:96352667-96353446 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:96357499-96358698 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96366753-96367253 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:96370580-96371523 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:96373730-96374416 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96375462-96375984 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:96413280-96414129 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr14:96414130-96414978

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The long noncoding RNA TUNAR modulates Wnt signaling and regulates human β-cell proliferation. Zhou AX, et al. Am J Physiol Endocrinol Metab, 2021 Apr 1. PMID 33682459
  2. Long noncoding RNA linc00617 exhibits oncogenic activity in breast cancer. Li H, et al. Mol Carcinog, 2017 Jan. PMID 26207516
  3. A putative long noncoding RNA-encoded micropeptide maintains cellular homeostasis in pancreatic β cells. Li M, et al. Mol Ther Nucleic Acids, 2021 Dec 3. PMID 34513312, Free PMC Article
  4. TUNAR lncRNA Encodes a Microprotein that Regulates Neural Differentiation and Neurite Formation by Modulating Calcium Dynamics. Senís E, et al. Front Cell Dev Biol, 2021. PMID 35036403, Free PMC Article
  5. Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes. Morán I, et al. Cell Metab, 2012 Oct 3. PMID 23040067, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The long noncoding RNA TUNAR modulates Wnt signaling and regulates human beta-cell proliferation.
    Title: The long noncoding RNA TUNAR modulates Wnt signaling and regulates human β-cell proliferation.
  2. This study found the human ortholog of TUNA, linc00617, was upregulated in breast cancer samples.
    Title: Long noncoding RNA linc00617 exhibits oncogenic activity in breast cancer.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ATPase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum calcium ion homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neuron projection morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cytosolic calcium ion concentration ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein TUNAR
Names
Human Islet Long Non Coding RNA 78
Tcl1 upstream neuron-associated lincRNA
beta cell- and neural cell-regulin
long intergenic non-protein coding RNA 617

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001416131.1 → NP_001403060.1  protein TUNAR isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL133167
    UniProtKB/TrEMBL
    A0A7I2V4K3

  2. NM_001416132.1 → NP_001403061.1  protein TUNAR isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL133167
    UniProtKB/Swiss-Prot
    A0A1B0GUV0

  3. NM_001416133.1 → NP_001403062.1  protein TUNAR isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL133167
    UniProtKB/Swiss-Prot
    A0A1B0GUV0

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    95876448..95925571
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    90107959..90157077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_038861.1: Suppressed sequence

    Description
    NR_038861.1: This RefSeq was removed because it is now thought that this gene does encode a protein.

  2. NR_132398.1: Suppressed sequence

    Description
    NR_132398.1: This RefSeq was removed because it is now thought that this gene does encode a protein.

  3. NR_132399.1: Suppressed sequence

    Description
    NR_132399.1: This RefSeq was removed because it is now thought that this gene does encode a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A1B0GTB2.2 GenPept UniProtKB/Swiss-Prot:A0A1B0GTB2

Gene LinkOut

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Molecular Biology Databases