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LINC00665 long intergenic non-protein coding RNA 665 [ Homo sapiens (human) ]

Gene ID: 100506930, updated on 25-Nov-2025
Official Symbol
LINC00665provided by HGNC
Official Full Name
long intergenic non-protein coding RNA 665provided by HGNC
Primary source
HGNC:HGNC:44323
See related
Ensembl:ENSG00000232677 AllianceGenome:HGNC:44323
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CIP2A-BP
Expression
Ubiquitous expression in thyroid (RPKM 5.2), kidney (RPKM 3.8) and 24 other tissues See more
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See LINC00665 in Genome Data Viewer
Location:
19q13.12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (36313061..36331753, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (38987945..39006648, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (36803963..36822620, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 565 Neighboring gene uncharacterized LOC107985304 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36724474-36724976 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36724977-36725478 Neighboring gene zinc finger protein 146 Neighboring gene MPRA-validated peak3458 silencer Neighboring gene MPRA-validated peak3459 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36735657-36736645 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:36736677-36736900 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:36737634-36738622 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36748697-36749315 Neighboring gene uncharacterized LOC124904707 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36759575-36760152 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36762631-36763222 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36770206-36770810 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36775291-36775913 Neighboring gene cyclin dependent kinase inhibitor 2A regulated lncRNA Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36786728-36787343 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36787344-36787958 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36790483-36791084 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36791085-36791685 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36793635-36794244 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36796811-36797424 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36818663-36819164 Neighboring gene MPRA-validated peak3460 silencer Neighboring gene ZFP14 zinc finger protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10548 Neighboring gene ZFP82 zinc finger protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14522

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Micropeptide CIP2A-BP encoded by LINC00665 inhibits triple-negative breast cancer progression. Guo B, et al. EMBO J, 2020 Jan 2. PMID 31755573, Free PMC Article
  2. LINC00665 activates Wnt/β-catenin signaling pathway to facilitate tumor progression of colorectal cancer via upregulating CTNNB1. Han T, et al. Exp Mol Pathol, 2021 Jun. PMID 33865827
  3. LINC00665 promotes HeLa cell proliferation, migration, invasion and epithelial-mesenchymal transition by activating the WNT-CTNNB1/β‑catenin signaling pathway. Xia L, et al. Sheng Li Xue Bao, 2021 Apr 25. PMID 33903885
  4. Downregulation of LINC00665 confers decreased cell proliferation and invasion via the miR-138-5p/E2F3 signaling pathway in NSCLC. Wang H, et al. Biomed Pharmacother, 2020 Jul. PMID 32403047
  5. Long non-coding RNA LINC00665 promotes metastasis of breast cancer cells by triggering EMT. Zhou JL, et al. Eur Rev Med Pharmacol Sci, 2020 Mar. PMID 32271427

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. STAU1-mediated CNBP mRNA degradation by LINC00665 alters stem cell characteristics in ovarian cancer.
    Title: STAU1-mediated CNBP mRNA degradation by LINC00665 alters stem cell characteristics in ovarian cancer.
  2. LINC00665 activating Wnt3a/beta-catenin signaling by bond with YBX1 promotes gastric cancer proliferation and metastasis.
    Title: LINC00665 activating Wnt3a/β-catenin signaling by bond with YBX1 promotes gastric cancer proliferation and metastasis.
  3. Overexpression of lncRNA LINC00665 inhibits the proliferation and chondroblast differentiation of bone marrow mesenchymal stem cells by targeting miR-214-3p.
    Title: Overexpression of lncRNA LINC00665 inhibits the proliferation and chondroblast differentiation of bone marrow mesenchymal stem cells by targeting miR-214-3p.
  4. Prognostic and clinicopathological values of LINC00665 in cancers: a systematic review and China population-based meta-analysis.
    Title: Prognostic and clinicopathological values of LINC00665 in cancers: a systematic review and China population-based meta-analysis.
  5. A short peptide LINC00665_18aa encoded by lncRNA LINC00665 suppresses the proliferation and migration of osteosarcoma cells through the regulation of the CREB1/RPS6KA3 interaction.
    Title: A short peptide LINC00665_18aa encoded by lncRNA LINC00665 suppresses the proliferation and migration of osteosarcoma cells through the regulation of the CREB1/RPS6KA3 interaction.
  6. A Feedback Loop of LINC00665 and the Wnt Signaling Pathway Expedites Osteosarcoma Cell Proliferation, Invasion, and Epithelial-Mesenchymal Transition.
    Title: A Feedback Loop of LINC00665 and the Wnt Signaling Pathway Expedites Osteosarcoma Cell Proliferation, Invasion, and Epithelial-Mesenchymal Transition.
  7. Hepatitis B Virus-Encoded HBsAg Contributes to Hepatocarcinogenesis by Inducing the Oncogenic Long Noncoding RNA LINC00665 through the NF-kappaB Pathway.
    Title: Hepatitis B Virus-Encoded HBsAg Contributes to Hepatocarcinogenesis by Inducing the Oncogenic Long Noncoding RNA LINC00665 through the NF-κB Pathway.
  8. LINC00665 affects the malignant biological behavior of ovarian cancer via the miR-148b-3p/KLF5.
    Title: LINC00665 affects the malignant biological behavior of ovarian cancer via the miR-148b-3p/KLF5.
  9. LncRNA LINC00665 Promotes Ovarian Cancer Cell Proliferation and Inhibits Apoptosis via Targeting miR-181a-5p/FHDC.
    Title: LncRNA LINC00665 Promotes Ovarian Cancer Cell Proliferation and Inhibits Apoptosis via Targeting miR-181a-5p/FHDC.
  10. MicroRNA-122-3p plays as the target of long non-coding RNA LINC00665 in repressing the progress of arthritis.
    Title: MicroRNA-122-3p plays as the target of long non-coding RNA LINC00665 in repressing the progress of arthritis.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Markers

Other Names

  • CIP2A binding peptide

Clone Names

  • FLJ33508, AC092296.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_038278.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC092296, BC041949
    Related
    ENST00000590622.5

  2. NR_038279.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal exon and includes two alternate 3' exons, compared to variant 1.
    Source sequence(s)
    AC092296, AI282277, BC041949, BU071001
    Related
    ENST00000449434.9

  3. NR_199171.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC092296
    Related
    ENST00000591372.3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    36313061..36331753 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    38987945..39006648 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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