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GVQW3 GVQW motif containing 3 [ Homo sapiens (human) ]

Gene ID: 100506127, updated on 13-Mar-2020

Summary

Official Symbol
GVQW3provided by HGNC
Official Full Name
GVQW motif containing 3provided by HGNC
Primary source
HGNC:HGNC:51239
See related
Ensembl:ENSG00000179240
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See GVQW3 in Genome Data Viewer
Location:
11q13.5
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (76381316..76414634)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (76092307..76125663)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369395 Neighboring gene THAP domain containing 12 Neighboring gene Sharpr-MPRA regulatory region 9860 Neighboring gene EMSY transcriptional repressor, BRCA2 interacting Neighboring gene long intergenic non-protein coding RNA 2757

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Clone Names

  • FLJ37770, FLJ43833

General protein information

Preferred Names
protein GVQW3
Names
GVQW motif-containing protein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282456.4NP_001269385.1  protein GVQW3 isoform a

    See identical proteins and their annotated locations for NP_001269385.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AP002360, BC040665, CK003340
    Consensus CDS
    CCDS73348.1
    UniProtKB/Swiss-Prot
    Q3ZCU0
    Related
    ENSP00000323821.4, ENST00000321844.6
    Conserved Domains (1) summary
    pfam13565
    Location:43108
    HTH_32; Homeodomain-like domain
  2. NM_001305225.3NP_001292154.1  protein GVQW3 isoform b

    See identical proteins and their annotated locations for NP_001292154.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) is intronless, where its 3' end extends past a splice site that is used in variant 1, resulting in an alternate 3' coding region and 3' UTR. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AI289296, AK125821, AP002360
    Consensus CDS
    CCDS81599.1
    UniProtKB/Swiss-Prot
    Q3ZCU0
    Related
    ENSP00000499610.1, ENST00000663165.1
    Conserved Domains (1) summary
    pfam13565
    Location:43108
    HTH_32; Homeodomain-like domain
  3. NM_001347884.2NP_001334813.1  protein GVQW3 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site and includes an alternate 3' exon, resulting in a novel 3' coding region and 3' UTR compared to variant 1. The encoded isoform (c) is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AP002360
    Related
    ENSP00000499731.1, ENST00000662483.1
  4. NM_001347885.2NP_001334814.1  protein GVQW3 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 3' coding region, resulting in a frameshift and an early stop codon compared to variant 1. The encoded isoform (d) is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AP002360, BC040665
    Consensus CDS
    CCDS86231.1
    UniProtKB/TrEMBL
    A0A0U1RQW1
    Related
    ENSP00000489195.1, ENST00000529331.1
    Conserved Domains (1) summary
    pfam13565
    Location:43108
    HTH_32; Homeodomain-like domain

RNA

  1. NR_130990.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because it lacks a significant portion of the coding region, including the translational start codon, as used in variant 1.
    Source sequence(s)
    AK125821, AP002360, BX103108
    Related
    ENST00000531207.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    76381316..76414634
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448282.1XP_024304050.1  protein GVQW3 isoform X2

    Conserved Domains (1) summary
    pfam13565
    Location:43108
    HTH_32; Homeodomain-like domain
  2. XM_024448281.1XP_024304049.1  protein GVQW3 isoform X1

    Conserved Domains (1) summary
    pfam13565
    Location:43108
    HTH_32; Homeodomain-like domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001013634.2: Suppressed sequence

    Description
    NM_001013634.2: This RefSeq was permanently suppressed because it is mostly repetitive sequence.
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