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PELATON plaque enriched lncRNA in atherosclerotic and inflammatory bowel macrophage regulation [ Homo sapiens (human) ]

Gene ID: 100506115, updated on 4-Mar-2025

Summary

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Official Symbol
PELATONprovided by HGNC
Official Full Name
plaque enriched lncRNA in atherosclerotic and inflammatory bowel macrophage regulationprovided by HGNC
Primary source
HGNC:HGNC:50328
See related
Ensembl:ENSG00000224397 AllianceGenome:HGNC:50328
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GCRL1; SMIM25; LINC01272
Expression
Biased expression in appendix (RPKM 11.9), lung (RPKM 11.2) and 6 other tissues See more
Orthologs
all
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Genomic context

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See PELATON in Genome Data Viewer
Location:
20q13.13
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (50267478..50279788)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (52037180..52049490)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (48884015..48896325)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985386 Neighboring gene uncharacterized LOC105372656 Neighboring gene MPRA-validated peak4248 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:48891163-48891664 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:48891665-48892164 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:48894009-48894546 Neighboring gene Sharpr-MPRA regulatory region 10045 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13019 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:48908810-48909546 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:48910660-48911160 Neighboring gene long intergenic non-protein coding RNA 1270 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:48921517-48922292 Neighboring gene Sharpr-MPRA regulatory region 5066 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:48925071-48925582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:48925583-48926093 Neighboring gene long intergenic non-protein coding RNA 1271 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:48937461-48938045 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:48938046-48938631 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:48938632-48939216 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18085 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18086 Neighboring gene uncharacterized LOC105372657 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:48971862-48972074

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. High expression of lncRNA PELATON serves as a risk factor for the incidence and prognosis of acute coronary syndrome. Chen L, et al. Sci Rep, 2022 May 16. PMID 35577857, Free PMC Article
  2. Novel Plaque Enriched Long Noncoding RNA in Atherosclerotic Macrophage Regulation (PELATON). Hung J, et al. Arterioscler Thromb Vasc Biol, 2020 Mar. PMID 31826651, Free PMC Article
  3. Discovery of PELATON links to the INHBA gene in the TGF-β pathway in colorectal cancer using a combination of bioinformatics and experimental investigations. Abutalebi M, et al. Int J Biol Macromol, 2024 Jun. PMID 38735606
  4. LINC01018 and SMIM25 sponged miR-182-5p in endometriosis revealed by the ceRNA network construction. Jiang L, et al. Int J Immunopathol Pharmacol, 2020 Jan-Dec. PMID 33237828, Free PMC Article
  5. Long ncRNA Landscape in the Ileum of Treatment-Naive Early-Onset Crohn Disease. Haberman Y, et al. Inflamm Bowel Dis, 2018 Jan 18. PMID 29361088, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Discovery of PELATON links to the INHBA gene in the TGF-beta pathway in colorectal cancer using a combination of bioinformatics and experimental investigations.
    Title: Discovery of PELATON links to the INHBA gene in the TGF-β pathway in colorectal cancer using a combination of bioinformatics and experimental investigations.
  2. High expression of lncRNA PELATON serves as a risk factor for the incidence and prognosis of acute coronary syndrome.
    Title: High expression of lncRNA PELATON serves as a risk factor for the incidence and prognosis of acute coronary syndrome.
  3. LINC01272 Suppressed Cell Multiplication and Induced Apoptosis Via Regulating MiR-7-5p/CRLS1 Axis in Lung Cancer.
    Title: LINC01272 Suppressed Cell Multiplication and Induced Apoptosis Via Regulating MiR-7-5p/CRLS1 Axis in Lung Cancer.
  4. LINC01018 and SMIM25 sponged miR-182-5p in endometriosis revealed by the ceRNA network construction.
    Title: LINC01018 and SMIM25 sponged miR-182-5p in endometriosis revealed by the ceRNA network construction.
  5. PELATON is a nuclear expressed, monocyte- and macrophage-specific lncRNA, upregulated in unstable atherosclerotic plaque.
    Title: Novel Plaque Enriched Long Noncoding RNA in Atherosclerotic Macrophage Regulation (PELATON).
  6. Co-expression and functional annotation enrichment analyses across several tissues and cell types showed that the upregulated LINC01272 is associated with a myeloid pro-inflammatory signature, whereas the downregulated HNF4A-AS1 exhibits association with an epithelial metabolic signature. The study identified significant correlations between LINC01272 and HNF4A-AS1 expression and more severe mucosal injury.
    Title: Long ncRNA Landscape in the Ileum of Treatment-Naive Early-Onset Crohn Disease.
  7. there were significantly positive correlations in KIF9AS1, LINC01272 and DIO3OS expression between IBD tissue and plasma samples. Therefore, the present study indicated that KIF9AS1, LINC01272 and DIO3OS may be potential diagnostic biomarkers for IBD.
    Title: KIF9‑AS1, LINC01272 and DIO3OS lncRNAs as novel biomarkers for inflammatory bowel disease.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

Homology

Other Names

  • GC-related lncRNA1
  • long intergenic non-protein coding RNA 1272
  • small integral membrane protein 25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_170991.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL354889
    Related
    ENST00000425497.6

  2. NR_170992.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL354889
    Related
    ENST00000622604.4

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    50267478..50279788
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    52037180..52049490
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001278655.2: Suppressed sequence

    Description
    NM_001278655.2: This RefSeq was removed because it is now thought that this gene does not encode a protein.
Nucleotide Protein
Heading Accession and Version

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