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IDUA alpha-L-iduronidase [ Canis lupus familiaris (dog) ]

Gene ID: 100505382, updated on 25-Jul-2026
Official Symbol
IDUAprovided by VGNC
Official Full Name
alpha-L-iduronidaseprovided by VGNC
Primary source
VGNC:VGNC:41867
See related
Ensembl:ENSCAFG00845001029 RGD:12249895
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
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See IDUA in Genome Data Viewer
Location:
chromosome: 3
Exon count:
18
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 3 NC_051807.1 (92515340..92532617, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 3 NC_006585.4 (93988643..94001108, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 3 NC_049224.1 (92130626..92143201, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 3 NC_049263.1 (91693928..91706431, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 3 NC_049744.1 (91746826..91759387, complement)

Chromosome 3 - NC_051807.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 212 Neighboring gene fibroblast growth factor receptor like 1 Neighboring gene uncharacterized LOC119881450 Neighboring gene uncharacterized LOC119871275 Neighboring gene solute carrier family 26 member 1 Neighboring gene diacylglycerol kinase theta Neighboring gene transmembrane protein 175

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Cloning and characterization of cDNA encoding canine alpha-L-iduronidase. mRNA deficiency in mucopolysaccharidosis I dog. Stoltzfus LJ, et al. J Biol Chem, 1992 Apr 5. PMID 1551868
  2. Architecture of the canine IDUA gene and mutation underlying canine mucopolysaccharidosis I. Menon KP, et al. Genomics, 1992 Nov. PMID 1339393
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables L-iduronidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
alpha-L-iduronidase
Names
iduronidase alpha-L-
XP_038516338.1
XP_038516339.1
XP_038516340.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313883.2 → NP_001300812.2  alpha-L-iduronidase precursor

    Status: PROVISIONAL

    Source sequence(s)
    JAAUVH010000011
    UniProtKB/Swiss-Prot
    Q01634
    Related
    ENSCAFP00845001447.1, ENSCAFT00845001836.1
    Conserved Domains (1) summary
    cl23725
    Location:29 → 542
    Glyco_hydro; Glycosyl hydrolases

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051807.1 Reference ROS_Cfam_1.0

    Range
    92515340..92532617 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038660411.1 → XP_038516339.1  alpha-L-iduronidase isoform X2

    UniProtKB/Swiss-Prot
    Q01634
    Conserved Domains (1) summary
    cl23725
    Location:29 → 542
    Glyco_hydro; Glycosyl hydrolases

  2. XM_038660412.1 → XP_038516340.1  alpha-L-iduronidase isoform X1

    UniProtKB/TrEMBL
    A0A8C0LTL8
    Conserved Domains (1) summary
    cl23725
    Location:1 → 438
    Glyco_hydro; Glycosyl hydrolases

  3. XM_038660410.1 → XP_038516338.1  alpha-L-iduronidase isoform X1

    UniProtKB/TrEMBL
    A0A8C0LTL8
    Conserved Domains (1) summary
    cl23725
    Location:1 → 438
    Glyco_hydro; Glycosyl hydrolases

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049263.1 Alternate UMICH_Zoey_3.1

    Range
    91693928..91706431 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049744.1 Alternate UNSW_CanFamBas_1.0

    Range
    91746826..91759387 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049224.1 Alternate UU_Cfam_GSD_1.0

    Range
    92130626..92143201 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006585.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    93988643..94001108 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q01634.1 GenPept UniProtKB/Swiss-Prot:Q01634

Gene LinkOut

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Research Materials