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Eef1akmt3 EEF1A lysine methyltransferase 3 [ Mus musculus (house mouse) ]

Gene ID: 100504608, updated on 11-Apr-2024

Summary

Official Symbol
Eef1akmt3provided by MGI
Official Full Name
EEF1A lysine methyltransferase 3provided by MGI
Primary source
MGI:MGI:3645330
See related
Ensembl:ENSMUSG00000080115 AllianceGenome:MGI:3645330
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam119b; Gm16109; EG546486; Mettl21b
Summary
Enables protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine methylation. Predicted to be located in centrosome; chromosome; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cytosol. Orthologous to human EEF1AKMT3 (EEF1A lysine methyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 2.4), kidney adult (RPKM 2.3) and 27 other tissues See more
Orthologs
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Genomic context

See Eef1akmt3 in Genome Data Viewer
Location:
10 D3; 10 74.5 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (126868654..126877883, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127032806..127042014, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene advillin Neighboring gene Ts translation elongation factor, mitochondrial Neighboring gene methyltransferase 1, tRNA methylguanosine Neighboring gene cytochrome P450, family 27, subfamily b, polypeptide 1 Neighboring gene membrane associated ring-CH-type finger 9

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
 
enables methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-lysine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein-lysine N-methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein-lysine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidyl-lysine methylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in peptidyl-lysine methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-lysine methylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
EEF1A lysine methyltransferase 3
Names
Methyltransferase-like protein 21B
Protein-lysine methyltransferase METTL21B
family with sequence similarity 119, member B
methyltransferase like 21B
NP_001191965.1
XP_017169241.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205036.1NP_001191965.1  EEF1A lysine methyltransferase 3

    See identical proteins and their annotated locations for NP_001191965.1

    Status: VALIDATED

    Source sequence(s)
    AC134329
    Consensus CDS
    CCDS56752.1
    UniProtKB/Swiss-Prot
    D3YWP0
    Related
    ENSMUSP00000111939.3, ENSMUST00000116231.4
    Conserved Domains (1) summary
    cl17173
    Location:37195
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    126868654..126877883 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313752.3XP_017169241.1  EEF1A lysine methyltransferase 3 isoform X1

    Conserved Domains (1) summary
    cl17173
    Location:15150
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...