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Ccdc170 coiled-coil domain containing 170 [ Mus musculus (house mouse) ]

Gene ID: 100504234, updated on 26-Sep-2022

Summary

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Official Symbol
Ccdc170provided by MGI
Official Full Name
coiled-coil domain containing 170provided by MGI
Primary source
MGI:MGI:2685067
See related
Ensembl:ENSMUSG00000019767 AllianceGenome:MGI:2685067
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm221
Summary
Predicted to enable microtubule binding activity. Predicted to be involved in microtubule cytoskeleton organization. Predicted to be located in ciliary basal body. Predicted to be active in Golgi apparatus. Orthologous to human CCDC170 (coiled-coil domain containing 170). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Ccdc170 in Genome Data Viewer
Location:
10; 10 A1
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (4432312..4514498)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (4482515..4564498)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 2 Neighboring gene required for meiotic nuclear division 1 homolog Neighboring gene acidic residue methyltransferase 1 Neighboring gene predicted gene, 22739 Neighboring gene glutathione S-transferase, pi 1 pseudogene Neighboring gene estrogen receptor 1 (alpha)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Three functional polymorphisms in CCDC170 were associated with osteoporosis phenotype. Liu X, et al. Biol Open, 2021 Apr 15. PMID 33785515, Free PMC Article
  2. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Three functional polymorphisms in CCDC170 were associated with osteoporosis phenotype.
    Title: Three functional polymorphisms in CCDC170 were associated with osteoporosis phenotype.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
coiled-coil domain-containing protein 170

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195672.2 → NP_001182601.1  coiled-coil domain-containing protein 170 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC156275, AC158617
    Consensus CDS
    CCDS56677.1
    UniProtKB/TrEMBL
    F6ST92
    Related
    ENSMUSP00000019901.6, ENSMUST00000019901.7
    Conserved Domains (1) summary
    COG1196
    Location:28 → 652
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. NM_001370992.1 → NP_001357921.1  coiled-coil domain-containing protein 170 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC156275, AC158617
    Consensus CDS
    CCDS87950.1
    UniProtKB/TrEMBL
    D3YXL0
    Related
    ENSMUSP00000115997.2, ENSMUST00000138112.8
    Conserved Domains (1) summary
    COG1196
    Location:34 → 658
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  3. NM_001370993.1 → NP_001357922.1  coiled-coil domain-containing protein 170 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC156275, AC158617
    Conserved Domains (2) summary
    COG1196
    Location:123 → 493
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR03346
    Location:434 → 566
    chaperone_ClpB; ATP-dependent chaperone ClpB

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    4432312..4514498
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155445.1 → XP_036011338.1  coiled-coil domain-containing protein 170 isoform X1

    Conserved Domains (2) summary
    COG1196
    Location:60 → 338
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:251 → 563
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  2. XM_017313751.2 → XP_017169240.1  coiled-coil domain-containing protein 170 isoform X2

    Conserved Domains (1) summary
    COG1196
    Location:38 → 371
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
Nucleotide Protein
Heading Accession and Version

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