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SLC17A4 solute carrier family 17 member 4 [ Homo sapiens (human) ]

Gene ID: 10050, updated on 23-Nov-2021

Summary

Official Symbol
SLC17A4provided by HGNC
Official Full Name
solute carrier family 17 member 4provided by HGNC
Primary source
HGNC:HGNC:10932
See related
Ensembl:ENSG00000146039 MIM:604216
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KAIA2138
Summary
Phosphate homeostasis is maintained by regulating intake, intestinal absorption, bone deposition and resorption, and renal excretion of phosphate. The central molecule in the control of phosphate excretion from the kidney is the sodium/phosphate cotransporter NPT1 (SLC17A1; MIM 182308), which is located in the renal proximal tubule. NPT1 uses the transmembrane electrochemical potential gradient of sodium to transport phosphate across the cell membrane. SLC17A4 is a similar sodium/phosphate cotransporter in the intestinal mucosa that plays an important role in the absorption of phosphate from the intestine (summary by Shibui et al., 1999 [PubMed 10319585]).[supplied by OMIM, Feb 2011]
Expression
Biased expression in small intestine (RPKM 10.3), duodenum (RPKM 9.0) and 5 other tissues See more
Orthologs
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Genomic context

See SLC17A4 in Genome Data Viewer
Location:
6p22.2
Exon count:
16
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (25754673..25781199)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (25754927..25781427)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 17 member 1 Neighboring gene H2B clustered histone 2, pseudogene Neighboring gene H2A clustered histone 2, pseudogene Neighboring gene solute carrier family 17 member 3 Neighboring gene H2A clustered histone 3, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
An atlas of genetic influences on human blood metabolites.
GeneReviews: Not available
Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.
GeneReviews: Not available
Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of solute carrier family 17 (sodium phosphate), member 4 (SLC17A4; KAIA2138) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA2138, MGC129623

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables sialic acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sodium:phosphate symporter activity TAS
Traceable Author Statement
more info
PubMed 
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in anion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phosphate-containing compound metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in sialic acid transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in sodium ion transport TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
probable small intestine urate exporter
Names
Na/PO4 cotransporter
putative small intestine sodium-dependent phosphate transport protein
solute carrier family 17 (sodium phosphate), member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286121.1NP_001273050.1  probable small intestine urate exporter isoform b

    See identical proteins and their annotated locations for NP_001273050.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in its 5' UTR and initiaties translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AK024903, AL391194, BC109208
    Consensus CDS
    CCDS75411.1
    UniProtKB/Swiss-Prot
    Q9Y2C5
    Related
    ENSP00000391345.3, ENST00000439485.6
    Conserved Domains (1) summary
    cl27298
    Location:1437
    UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]
  2. NM_005495.3NP_005486.1  probable small intestine urate exporter isoform a

    See identical proteins and their annotated locations for NP_005486.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (a).
    Source sequence(s)
    AB020527, AL391194
    Consensus CDS
    CCDS4564.1
    UniProtKB/Swiss-Prot
    Q9Y2C5
    UniProtKB/TrEMBL
    A0A024R013
    Related
    ENSP00000367137.4, ENST00000377905.9
    Conserved Domains (1) summary
    cl27298
    Location:30491
    UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    25754673..25781199
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514213.2XP_011512515.1  probable small intestine urate exporter isoform X3

    Conserved Domains (2) summary
    cd06174
    Location:98402
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00894
    Location:30413
    2A0114euk; Na(+)-dependent inorganic phosphate cotransporter
  2. XM_011514217.2XP_011512519.1  probable small intestine urate exporter isoform X7

    Conserved Domains (1) summary
    cd06174
    Location:117304
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  3. XM_011514219.2XP_011512521.1  probable small intestine urate exporter isoform X9

    UniProtKB/Swiss-Prot
    Q9Y2C5
    Conserved Domains (1) summary
    cd06174
    Location:88250
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  4. XM_017010150.1XP_016865639.1  probable small intestine urate exporter isoform X4

  5. XM_011514214.2XP_011512516.1  probable small intestine urate exporter isoform X5

    Conserved Domains (1) summary
    cd06174
    Location:98334
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  6. XM_017010151.1XP_016865640.1  probable small intestine urate exporter isoform X10

  7. XM_011514215.2XP_011512517.1  probable small intestine urate exporter isoform X6

    Conserved Domains (1) summary
    cd06174
    Location:98330
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  8. XM_024446297.1XP_024302065.1  probable small intestine urate exporter isoform X2

    Conserved Domains (1) summary
    cl27298
    Location:1437
    UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]
  9. XM_024446295.1XP_024302063.1  probable small intestine urate exporter isoform X1

    Conserved Domains (1) summary
    cl27298
    Location:30491
    UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]
  10. XM_024446296.1XP_024302064.1  probable small intestine urate exporter isoform X1

    Conserved Domains (1) summary
    cl27298
    Location:30491
    UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]
  11. XM_024446294.1XP_024302062.1  probable small intestine urate exporter isoform X1

    Conserved Domains (1) summary
    cl27298
    Location:30491
    UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]
  12. XM_011514211.1XP_011512513.1  probable small intestine urate exporter isoform X2

    See identical proteins and their annotated locations for XP_011512513.1

    UniProtKB/Swiss-Prot
    Q9Y2C5
    Conserved Domains (1) summary
    cl27298
    Location:1437
    UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]
  13. XM_011514218.2XP_011512520.1  probable small intestine urate exporter isoform X8

    Conserved Domains (1) summary
    cd06174
    Location:2272
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

RNA

  1. XR_925997.1 RNA Sequence

  2. XR_925996.1 RNA Sequence

  3. XR_925998.1 RNA Sequence

  4. XR_925999.1 RNA Sequence

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