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sox8 SRY-box 8 [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 100497725, updated on 6-Jul-2026
Official Symbol
sox8provided by Xenbase
Official Full Name
SRY-box 8provided by Xenbase
Primary source
Xenbase:XB-GENE-480865
See related
Ensembl:ENSXETG00000034823 AllianceGenome:Xenbase:XB-GENE-480865
Gene type
protein coding
RefSeq status
MODEL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including negative regulation of transcription by RNA polymerase II; nervous system development; and neural crest cell development. Predicted to be active in nucleus. Is expressed in mesenchyme; musculoskeletal system; nervous system; pharyngeal arch; and primary germ layer. Orthologous to human SOX8 (SRY-box transcription factor 8). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
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See sox8 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
3
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 9 NC_030685.2 (17263637..17275708)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 9 NC_030685.1 (11439991..11450119)

Chromosome 9 - NC_030685.2Genomic Context describing neighboring genes Neighboring gene testis expressed 2 gene 1 Neighboring gene lipase maturation factor 1 Neighboring gene somatostatin receptor type 2 Neighboring gene somatostatin receptor 5

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in enteric nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in morphogenesis of an epithelium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neural crest cell development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neural crest formation IEA
Inferred from Electronic Annotation
more info
  
involved_in peripheral nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
transcription factor SOX-8
Names
SRY (sex determining region Y)-box 8

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RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030685.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    17263637..17275708
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_002932269.5 → XP_002932315.2  transcription factor SOX-8

    UniProtKB/TrEMBL
    A0A6I8S579
    Related
    ENSXETP00000091960.1, ENSXETT00000104208.2
    Conserved Domains (2) summary
    cd01388
    Location:104 → 174
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam12444
    Location:39 → 94
    Sox_N; Sox developmental protein N terminal
Nucleotide Protein Strain
Heading Accession and Version

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