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jag2 jagged 2 [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 100497180, updated on 12-Aug-2026
Official Symbol
jag2provided by Xenbase
Official Full Name
jagged 2provided by Xenbase
Primary source
Xenbase:XB-GENE-485160
See related
Ensembl:ENSXETG00000033099 AllianceGenome:Xenbase:XB-GENE-485160
Gene type
protein coding
RefSeq status
MODEL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Summary
Predicted to enable Notch binding activity and calcium ion binding activity. Predicted to act upstream of or within Notch signaling pathway and cell differentiation. Predicted to be located in extracellular region and membrane. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy. Orthologous to human JAG2 (jagged canonical Notch ligand 2). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
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See jag2 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
26
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 8 NC_030684.2 (100223238..100276306, complement)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 8 NC_030684.1 (79980957..80033927, complement)

Chromosome 8 - NC_030684.2Genomic Context describing neighboring genes Neighboring gene cell division cycle associated 4 Neighboring gene G protein-coupled receptor 132 Neighboring gene BRF1 general transcription factor IIIB subunit Neighboring gene BTB (POZ) domain containing 6 Neighboring gene protein phosphatase 1 regulatory subunit 36

Go to nucleotide: Graphics FASTA GenBank

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables Notch binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Notch binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in animal gross anatomical part developmental process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell communication IEA
Inferred from Electronic Annotation
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
protein jagged-2

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030684.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    100223238..100276306 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_031890984.1 → XP_031746844.1  protein jagged-2 isoform X2

    UniProtKB/TrEMBL
    A0A6I8REQ8
    Related
    ENSXETP00000083448.2, ENSXETT00000104210.2
    Conserved Domains (5) summary
    smart00215
    Location:832 → 902
    VWC_out; von Willebrand factor (vWF) type C domain
    cd00054
    Location:300 → 338
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00008
    Location:344 → 372
    EGF; EGF-like domain
    pfam01414
    Location:171 → 233
    DSL; Delta serrate ligand
    pfam07657
    Location:29 → 103
    MNNL; N-terminus of Notch ligand

  2. XM_012969442.3 → XP_012824896.2  protein jagged-2 isoform X1

    UniProtKB/TrEMBL
    A0A6I8Q433
    Related
    ENSXETP00000062855.3, ENSXETT00000060633.3
    Conserved Domains (5) summary
    smart00215
    Location:870 → 940
    VWC_out; von Willebrand factor (vWF) type C domain
    cd00054
    Location:300 → 338
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00008
    Location:344 → 372
    EGF; EGF-like domain
    pfam01414
    Location:171 → 233
    DSL; Delta serrate ligand
    pfam07657
    Location:29 → 103
    MNNL; N-terminus of Notch ligand
Nucleotide Protein Strain
Heading Accession and Version

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