hspa5 heat shock protein family A (Hsp70) member 5 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: hspa5provided by Xenbase
Official Full Name: heat shock protein family A (Hsp70) member 5provided by Xenbase
Primary source: Xenbase:XB-GENE-480060
See related: Ensembl:ENSXETG00000016838 AllianceGenome:Xenbase:XB-GENE-480060
Gene type: protein coding
RefSeq status: MODEL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: BiP; XAP-1; grp78
Summary: Predicted to enable ATP hydrolysis activity; heat shock protein binding activity; and protein folding chaperone. Predicted to be involved in ERAD pathway; endoplasmic reticulum unfolded protein response; and protein folding. Predicted to be located in endoplasmic reticulum. Predicted to be part of endoplasmic reticulum chaperone complex. Predicted to be active in endoplasmic reticulum lumen; membrane; and nucleus. Human ortholog(s) of this gene implicated in dopamine beta-hydroxylase deficiency. Orthologous to human HSPA5 (heat shock protein family A (Hsp70) member 5). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs: all
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Try the new Transcripts and proteins table

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	8	NC_030684.2 (28183867..28190773)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	8	NC_030684.1 (10425889..10432795)

Chromosome 8 - NC_030684.2 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables heat shock protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein folding chaperone	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum unfolded protein response	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein refolding	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of endoplasmic reticulum chaperone complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum lumen	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info