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nkx2-3 NK2 homeobox 3 [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 100486189, updated on 6-Jul-2026
Official Symbol
nkx2-3provided by Xenbase
Official Full Name
NK2 homeobox 3provided by Xenbase
Primary source
Xenbase:XB-GENE-852996
See related
Ensembl:ENSXETG00000036831 AllianceGenome:Xenbase:XB-GENE-852996
Gene type
protein coding
RefSeq status
MODEL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as
nkx2.3; nkx-2.3; xnkx2-3; nkx2-3-a; nkx2-3-b; xnkx-2.3
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Orthologous to human NKX2-3 (NK2 homeobox 3). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Try the new Transcripts and proteins table
See nkx2-3 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
3
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 7 NC_030683.2 (35251339..35269049)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 7 NC_030683.1 (27016768..27034391)

Chromosome 7 - NC_030683.2Genomic Context describing neighboring genes Neighboring gene cyclin and CBS domain divalent metal cation transport mediator 1 Neighboring gene glutamic-oxaloacetic transaminase 1 Neighboring gene NK3 homeobox 3 Neighboring gene solute carrier family 25 member 28

Go to nucleotide: Graphics FASTA GenBank

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
homeobox protein Nkx-2.3

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030683.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    35251339..35269049
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_002937188.5 → XP_002937234.1  homeobox protein Nkx-2.3

    See identical proteins and their annotated locations for XP_002937234.1

    UniProtKB/TrEMBL
    A0A6I8Q8L6
    Related
    ENSXETP00000065791.1, ENSXETT00000089378.2
    Conserved Domains (1) summary
    pfam00046
    Location:149 → 203
    Homeobox; Homeobox domain
Nucleotide Protein Strain
Heading Accession and Version

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