TRIM37 tripartite motif containing 37 [Pongo abelii (Sumatran orangutan)] - Gene

Summary

Gene symbol: TRIM37
Gene description: tripartite motif containing 37
Locus tag: CR201_G0012084
See related: Ensembl:ENSPPYG00000008815
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Pongo abelii
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPonAbe1-v2.0_pri (GCF_028885655.2)	19	NC_072004.2 (56755398..56878829)
RS_2023_04	previous assembly	NHGRI_mPonAbe1-v1.1-hic.freeze_pri (GCF_028885655.1)	17	NC_072002.1 (59063451..59186385)

Chromosome 19 - NC_072004.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

PMC310730P3 (e-PCR)
- UniSTS:272661

D17S1670 (e-PCR)
- UniSTS:16410

G20499 (e-PCR)
- UniSTS:2352

A005U07 (e-PCR)
- UniSTS:2353

A009B30 (e-PCR)
- UniSTS:6705

G42202 (e-PCR)
- UniSTS:93305

G42207 (e-PCR)
- UniSTS:93310

G42231 (e-PCR)
- UniSTS:93334

RH91179 (e-PCR)
- UniSTS:92332

D17S1449E (e-PCR)
- UniSTS:150489

G32388 (e-PCR)
- UniSTS:116976

A007E14 (e-PCR)
- UniSTS:57333

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables tumor necrosis factor receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of NF-kappaB transcription factor activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of centriole replication	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of NF-kappaB transcription factor activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein autoubiquitination	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in aggresome	IEA Inferred from Electronic Annotation more info	PubMed
located_in peroxisome	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: E3 ubiquitin-protein ligase TRIM37

NP_001124935.1

EC 2.3.2.27

XP_024090074.1

EC 2.3.2.27

XP_024090075.1

EC 2.3.2.27

XP_024090076.1

EC 2.3.2.27

XP_054391292.1

EC 2.3.2.27

XP_054391293.1

EC 2.3.2.27

XP_063574018.1

EC 2.3.2.27

XP_063574019.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001131463.1 → NP_001124935.1 E3 ubiquitin-protein ligase TRIM37

See identical proteins and their annotated locations for NP_001124935.1

Status: VALIDATED

Source sequence(s)

CR538531, CR857712

UniProtKB/TrEMBL

A0A8I5TRS5, Q5RE26

Related

ENSPPYP00000030340.1, ENSPPYT00000052464.1

Conserved Domains (4) summary

smart00502
Location:132 → 254

BBC; B-Box C-terminal domain

cd00162
Location:15 → 58

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd03773
Location:273 → 406

MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...

pfam00643
Location:90 → 132

zf-B_box; B-box zinc finger

RefSeqs of Annotated Genomes: GCF_028885655.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

Genomic

NC_072004.2 Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

Range

56755398..56878829

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024234306.3 → XP_024090074.1 E3 ubiquitin-protein ligase TRIM37 isoform X1

UniProtKB/TrEMBL

A0A8I5TCU4, A0A8I5TRS5

Conserved Domains (4) summary

smart00502
Location:132 → 254

BBC; B-Box C-terminal domain

smart00336
Location:91 → 132

BBOX; B-Box-type zinc finger

cd03773
Location:273 → 406

MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...

cd16619
Location:13 → 55

mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins
XM_024234307.3 → XP_024090075.1 E3 ubiquitin-protein ligase TRIM37 isoform X2

UniProtKB/TrEMBL

A0A2J8W7M0, A0A8I5TRS5, H2NVA2

Related

ENSPPYP00000009897.3

Conserved Domains (4) summary

smart00502
Location:132 → 254

BBC; B-Box C-terminal domain

smart00336
Location:91 → 132

BBOX; B-Box-type zinc finger

cd03773
Location:273 → 406

MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...

cd16619
Location:13 → 55

mRING-HC-C4C4_TRIM37_C-VIII; Modified RING finger, HC subclass (C4C4-type), found in tripartite motif-containing protein 37 (TRIM37) and similar proteins
XM_063717949.1 → XP_063574019.1 E3 ubiquitin-protein ligase TRIM37 isoform X5
XM_054535317.2 → XP_054391292.1 E3 ubiquitin-protein ligase TRIM37 isoform X6

UniProtKB/TrEMBL

A0A8I5UN51
XM_024234308.3 → XP_024090076.1 E3 ubiquitin-protein ligase TRIM37 isoform X3

UniProtKB/TrEMBL

A0A8I5TRS5

Conserved Domains (4) summary

smart00502
Location:98 → 220

BBC; B-Box C-terminal domain

smart00336
Location:57 → 98

BBOX; B-Box-type zinc finger

cd03773
Location:239 → 372

MATH_TRIM37; Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. ...

cl17238
Location:6 → 21

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
XM_063717948.1 → XP_063574018.1 E3 ubiquitin-protein ligase TRIM37 isoform X4

UniProtKB/TrEMBL

A0A2J8W7M3, A0A8I5U8X9
XM_054535318.2 → XP_054391293.1 E3 ubiquitin-protein ligase TRIM37 isoform X7