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CTSB cathepsin B [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 100424758, updated on 10-Feb-2026
Official Symbol
CTSBprovided by VGNC
Official Full Name
cathepsin Bprovided by VGNC
Primary source
VGNC:VGNC:71552
See related
Ensembl:ENSMMUG00000019212
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
all
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See CTSB in Genome Data Viewer
Location:
chromosome: 8
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2025_08 current T2T-MMU8v2.0 (GCF_049350105.2) 8 NC_133413.1 (9426209..9450655)
103 previous assembly Mmul_10 (GCF_003339765.1) 8 NC_041761.1 (8711530..8736343)

Chromosome 8 - NC_133413.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114680173 Neighboring gene defensin beta 135 Neighboring gene defensin beta 136 Neighboring gene uncharacterized LOC144330674 Neighboring gene farnesyl-diphosphate farnesyltransferase 1 Neighboring gene activated RNA polymerase II transcriptional coactivator p15 pseudogene

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Running-Induced Systemic Cathepsin B Secretion Is Associated with Memory Function. Moon HY, et al. Cell Metab, 2016 Aug 9. PMID 27345423, Free PMC Article
  2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
cathepsin B
NP_001181828.2
XP_077798344.1
XP_077798345.1
XP_077798346.1
XP_077798347.1
XP_077798348.1
XP_077798350.1
XP_077798351.1
XP_077798352.1
XP_077798353.1
XP_077798354.1
XP_077798355.1
XP_077798356.1
XP_077798357.1
XP_077798358.1
XP_077798359.1
XP_077798361.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001194899.2 → NP_001181828.2  cathepsin B precursor

    Status: PROVISIONAL

    Source sequence(s)
    QNVO02000446
    UniProtKB/TrEMBL
    A0A1D5QVT4, F6QQ66, G7N0H2
    Conserved Domains (2) summary
    cd02620
    Location:81 → 328
    Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
    pfam08127
    Location:26 → 65
    Propeptide_C1; Peptidase family C1 propeptide

RefSeqs of Annotated Genomes: GCF_049350105.2-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference T2T-MMU8v2.0

Genomic

  1. NC_133413.1 Reference T2T-MMU8v2.0

    Range
    9426209..9450655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_077942231.1 → XP_077798357.1  cathepsin B isoform X2

    UniProtKB/TrEMBL
    G7N0H2, I0FJS6

  2. XM_077942226.1 → XP_077798352.1  cathepsin B isoform X2

    UniProtKB/TrEMBL
    G7N0H2, I0FJS6

  3. XM_077942233.1 → XP_077798359.1  cathepsin B isoform X4

    UniProtKB/TrEMBL
    G7N0H2

  4. XM_077942230.1 → XP_077798356.1  cathepsin B isoform X2

    UniProtKB/TrEMBL
    G7N0H2, I0FJS6

  5. XM_077942229.1 → XP_077798355.1  cathepsin B isoform X2

    UniProtKB/TrEMBL
    G7N0H2, I0FJS6

  6. XM_077942228.1 → XP_077798354.1  cathepsin B isoform X2

    UniProtKB/TrEMBL
    G7N0H2, I0FJS6

  7. XM_077942225.1 → XP_077798351.1  cathepsin B isoform X2

    UniProtKB/TrEMBL
    G7N0H2, I0FJS6

  8. XM_077942235.1 → XP_077798361.1  cathepsin B isoform X4

    UniProtKB/TrEMBL
    G7N0H2

  9. XM_077942232.1 → XP_077798358.1  cathepsin B isoform X3

  10. XM_077942218.1 → XP_077798344.1  cathepsin B isoform X1

    UniProtKB/TrEMBL
    A0A5F8AL86

  11. XM_077942222.1 → XP_077798348.1  cathepsin B isoform X2

    UniProtKB/TrEMBL
    G7N0H2, I0FJS6

  12. XM_077942224.1 → XP_077798350.1  cathepsin B isoform X2

    UniProtKB/TrEMBL
    G7N0H2, I0FJS6

  13. XM_077942221.1 → XP_077798347.1  cathepsin B isoform X2

    UniProtKB/TrEMBL
    G7N0H2, I0FJS6

  14. XM_077942220.1 → XP_077798346.1  cathepsin B isoform X2

    UniProtKB/TrEMBL
    G7N0H2, I0FJS6

  15. XM_077942219.1 → XP_077798345.1  cathepsin B isoform X2

    UniProtKB/TrEMBL
    G7N0H2, I0FJS6

  16. XM_077942227.1 → XP_077798353.1  cathepsin B isoform X2

    UniProtKB/TrEMBL
    G7N0H2, I0FJS6
Nucleotide Protein
Heading Accession and Version

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