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RNF8 ring finger protein 8 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 100424611, updated on 10-Feb-2026
Official Symbol
RNF8provided by VGNC
Official Full Name
ring finger protein 8provided by VGNC
Primary source
VGNC:VGNC:76708
See related
Ensembl:ENSMMUG00000011573
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
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Try the new Transcripts and proteins table
See RNF8 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2025_08 current T2T-MMU8v2.0 (GCF_049350105.2) 4 NC_133409.1 (144846642..144885440, complement)
103 previous assembly Mmul_10 (GCF_003339765.1) 4 NC_041757.1 (132036484..132075643, complement)

Chromosome 4 - NC_133409.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 167 Neighboring gene cap methyltransferase 1 Neighboring gene uncharacterized LOC100427362 Neighboring gene uncharacterized LOC144340392 Neighboring gene cell division control protein 42 homolog pseudogene Neighboring gene TBC1 domain family member 22B Neighboring gene uncharacterized LOC144340391

Markers

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables histone binding IEA
Inferred from Electronic Annotation
more info
PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
PubMed 
Process Evidence Code Pubs
involved_in double-strand break repair IEA
Inferred from Electronic Annotation
more info
PubMed 
involved_in protein K48-linked ubiquitination IEA
Inferred from Electronic Annotation
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
PubMed 
located_in site of double-strand break IEA
Inferred from Electronic Annotation
more info
PubMed 
part_of ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
PubMed 
Preferred Names
E3 ubiquitin-protein ligase RNF8
NP_001252758.1
XP_014991615.2
XP_028702431.1
XP_077854397.1
XP_077854398.1
XP_077854399.1
XP_077854400.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001265829.1NP_001252758.1  E3 ubiquitin-protein ligase RNF8

    See identical proteins and their annotated locations for NP_001252758.1

    Status: PROVISIONAL

    Source sequence(s)
    JU477714
    UniProtKB/TrEMBL
    F7BPC7, F7BPD6, G7MP74
    Related
    ENSMMUP00000001722.3, ENSMMUT00000001826.4
    Conserved Domains (5) summary
    COG1716
    Location:21109
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:17110
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd00162
    Location:403445
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd16269
    Location:395405
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:284405
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_049350105.2-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference T2T-MMU8v2.0

Genomic

  1. NC_133409.1 Reference T2T-MMU8v2.0

    Range
    144846642..144885440 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_077998271.1XP_077854397.1  E3 ubiquitin-protein ligase RNF8 isoform X1

    UniProtKB/TrEMBL
    G7MP74
  2. XM_028846598.2XP_028702431.1  E3 ubiquitin-protein ligase RNF8 isoform X2

    UniProtKB/TrEMBL
    G7MP74
    Conserved Domains (3) summary
    cd00060
    Location:17110
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam09787
    Location:265389
    Golgin_A5; Golgin subfamily A member 5
    cl17238
    Location:377406
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  3. XM_015136129.3XP_014991615.2  E3 ubiquitin-protein ligase RNF8 isoform X3

    UniProtKB/TrEMBL
    G7MP74
  4. XM_077998273.1XP_077854399.1  E3 ubiquitin-protein ligase RNF8 isoform X5

    UniProtKB/TrEMBL
    G7MP74
  5. XM_077998274.1XP_077854400.1  E3 ubiquitin-protein ligase RNF8 isoform X6

  6. XM_077998272.1XP_077854398.1  E3 ubiquitin-protein ligase RNF8 isoform X4

    UniProtKB/TrEMBL
    G7MP74

RNA

  1. XR_013415996.1 RNA Sequence

  2. XR_001444221.3 RNA Sequence