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LRRC8D leucine rich repeat containing 8 VRAC subunit D [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 100423127, updated on 10-Feb-2026
Official Symbol
LRRC8Dprovided by VGNC
Official Full Name
leucine rich repeat containing 8 VRAC subunit Dprovided by VGNC
Primary source
VGNC:VGNC:81441
Locus tag
EGK_00953
See related
Ensembl:ENSMMUG00000012828
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
all
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Try the new Transcripts and proteins table
See LRRC8D in Genome Data Viewer
Location:
chromosome: 1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2025_08 current T2T-MMU8v2.0 (GCF_049350105.2) 1 NC_133406.1 (150706990..150825803, complement)
103 previous assembly Mmul_10 (GCF_003339765.1) 1 NC_041754.1 (134560483..134678963, complement)

Chromosome 1 - NC_133406.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC144332661 Neighboring gene gem-associated protein 8 pseudogene Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC144332674 Neighboring gene leucine rich repeat containing 8 VRAC subunit C

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
  2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
volume-regulated anion channel subunit LRRC8D
Names
leucine rich repeat containing 8 family member D
leucine-rich repeat-containing protein 8D

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001266553.1 → NP_001253482.1  volume-regulated anion channel subunit LRRC8D

    See identical proteins and their annotated locations for NP_001253482.1

    Status: PROVISIONAL

    Source sequence(s)
    JU473066
    UniProtKB/TrEMBL
    A0A8J8XNZ6, F6TCH4, G7MHV8
    Conserved Domains (5) summary
    COG4886
    Location:596 → 825
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:515 → 536
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:637 → 659
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1 → 384
    Pannexin_like; Pannexin-like TM region of LRRC8
    NF033190
    Location:456 → 702
    inl_like_NEAT_1; NEAT domain-containing leucine-rich repeat protein

RefSeqs of Annotated Genomes: GCF_049350105.2-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference T2T-MMU8v2.0

Genomic

  1. NC_133406.1 Reference T2T-MMU8v2.0

    Range
    150706990..150825803 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_077951980.1 → XP_077808106.1  volume-regulated anion channel subunit LRRC8D isoform X1

    UniProtKB/TrEMBL
    A0A8J8XNZ6, F6TCH4, G7MHV8

  2. XM_015143550.3 → XP_014999036.1  volume-regulated anion channel subunit LRRC8D isoform X1

    UniProtKB/TrEMBL
    A0A8J8XNZ6, F6TCH4, G7MHV8
    Conserved Domains (5) summary
    COG4886
    Location:596 → 825
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:515 → 536
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:637 → 659
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1 → 384
    Pannexin_like; Pannexin-like TM region of LRRC8
    NF033190
    Location:456 → 702
    inl_like_NEAT_1; NEAT domain-containing leucine-rich repeat protein

  3. XM_077950937.1 → XP_077807063.1  volume-regulated anion channel subunit LRRC8D isoform X1

    UniProtKB/TrEMBL
    A0A8J8XNZ6, F6TCH4, G7MHV8

  4. XM_077953548.1 → XP_077809674.1  volume-regulated anion channel subunit LRRC8D isoform X1

    UniProtKB/TrEMBL
    A0A8J8XNZ6, F6TCH4, G7MHV8

  5. XM_077947890.1 → XP_077804016.1  volume-regulated anion channel subunit LRRC8D isoform X1

    UniProtKB/TrEMBL
    A0A8J8XNZ6, F6TCH4, G7MHV8

  6. XM_077949180.1 → XP_077805306.1  volume-regulated anion channel subunit LRRC8D isoform X1

    UniProtKB/TrEMBL
    A0A8J8XNZ6, F6TCH4, G7MHV8

  7. XM_077952255.1 → XP_077808381.1  volume-regulated anion channel subunit LRRC8D isoform X1

    UniProtKB/TrEMBL
    A0A8J8XNZ6, F6TCH4, G7MHV8

  8. XM_077948197.1 → XP_077804323.1  volume-regulated anion channel subunit LRRC8D isoform X1

    UniProtKB/TrEMBL
    A0A8J8XNZ6, F6TCH4, G7MHV8

  9. XM_028848277.2 → XP_028704110.1  volume-regulated anion channel subunit LRRC8D isoform X1

    UniProtKB/TrEMBL
    A0A8J8XNZ6, F6TCH4, G7MHV8
    Conserved Domains (5) summary
    COG4886
    Location:596 → 825
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:515 → 536
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:637 → 659
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1 → 384
    Pannexin_like; Pannexin-like TM region of LRRC8
    NF033190
    Location:456 → 702
    inl_like_NEAT_1; NEAT domain-containing leucine-rich repeat protein

  10. XM_015143557.3 → XP_014999043.1  volume-regulated anion channel subunit LRRC8D isoform X1

    UniProtKB/TrEMBL
    A0A8J8XNZ6, F6TCH4, G7MHV8
    Related
    ENSMMUP00000016852.2
    Conserved Domains (5) summary
    COG4886
    Location:596 → 825
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:515 → 536
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:637 → 659
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1 → 384
    Pannexin_like; Pannexin-like TM region of LRRC8
    NF033190
    Location:456 → 702
    inl_like_NEAT_1; NEAT domain-containing leucine-rich repeat protein

  11. XM_077951449.1 → XP_077807575.1  volume-regulated anion channel subunit LRRC8D isoform X1

    UniProtKB/TrEMBL
    A0A8J8XNZ6, F6TCH4, G7MHV8

  12. XM_077953124.1 → XP_077809250.1  volume-regulated anion channel subunit LRRC8D isoform X1

    UniProtKB/TrEMBL
    A0A8J8XNZ6, F6TCH4, G7MHV8

  13. XM_077950298.1 → XP_077806424.1  volume-regulated anion channel subunit LRRC8D isoform X1

    UniProtKB/TrEMBL
    A0A8J8XNZ6, F6TCH4, G7MHV8

  14. XM_077949784.1 → XP_077805910.1  volume-regulated anion channel subunit LRRC8D isoform X1

    UniProtKB/TrEMBL
    A0A8J8XNZ6, F6TCH4, G7MHV8

  15. XM_077952704.1 → XP_077808830.1  volume-regulated anion channel subunit LRRC8D isoform X1

    UniProtKB/TrEMBL
    A0A8J8XNZ6, F6TCH4, G7MHV8

  16. XM_077954085.1 → XP_077810211.1  volume-regulated anion channel subunit LRRC8D isoform X1

    UniProtKB/TrEMBL
    A0A8J8XNZ6, F6TCH4, G7MHV8
Nucleotide Protein
Heading Accession and Version

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