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IGLL5 immunoglobulin lambda like polypeptide 5 [ Homo sapiens (human) ]

Gene ID: 100423062, updated on 4-Oct-2020

Summary

Official Symbol
IGLL5provided by HGNC
Official Full Name
immunoglobulin lambda like polypeptide 5provided by HGNC
Primary source
HGNC:HGNC:38476
See related
Ensembl:ENSG00000254709
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IGL; IGLV; VL-MAR
Summary
This gene encodes one of the immunoglobulin lambda-like polypeptides. It is located within the immunoglobulin lambda locus but it does not require somatic rearrangement for expression. The first exon of this gene is unrelated to immunoglobulin variable genes; the second and third exons are the immunoglobulin lambda joining 1 and the immunoglobulin lambda constant 1 gene segments. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Orthologs

Genomic context

See IGLL5 in Genome Data Viewer
Location:
22q11.22
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (22887816..22896111)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (23229960..23238014)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene immunoglobulin lambda locus Neighboring gene uncharacterized LOC105372948 Neighboring gene uncharacterized LOC102724638 Neighboring gene immunoglobulin lambda variable 3-1 Neighboring gene microRNA 5571 Neighboring gene immunoglobulin lambda joining 1 Neighboring gene immunoglobulin lambda constant 1 Neighboring gene immunoglobulin lambda joining 2 Neighboring gene immunoglobulin lambda constant 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immunoglobulin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
complement activation, classical pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phagocytosis, engulfment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phagocytosis, recognition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of B cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
immunoglobulin complex, circulating IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
immunoglobulin lambda-like polypeptide 5
Names
G lambda-1
anti HBs antibody light-chain Fab fragment
germline immunoglobulin lambda 1
immunoglobin anti-granzymeB light chain variable region
immunoglobulin lambda 1 light chain
immunoglobulin lambda 2 light chain
immunoglobulin lambda 3 light chain
immunoglobulin lambda light chain variable region
immunoglobulin lambda-3 surrogate light chain
immunoglobulin light chain variable region EM1-PPS-4-L1-1
omega light chain protein 14.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_000002.1 

    Range
    853944..861998
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178126.2NP_001171597.1  immunoglobulin lambda-like polypeptide 5 isoform 1

    See identical proteins and their annotated locations for NP_001171597.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA847784, AC245028, AJ318022, BG756003
    Consensus CDS
    CCDS54506.1
    UniProtKB/Swiss-Prot
    B9A064
    Related
    ENSP00000431254.1, ENST00000526893.6
    Conserved Domains (1) summary
    cd07699
    Location:115207
    IgC_L; Immunoglobulin Constant domain
  2. NM_001256296.2NP_001243225.1  immunoglobulin lambda-like polypeptide 5 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the central coding region, and uses an alternate downstream start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AA847784, AC245028, AJ318022, AJ319669, AJ319670
    Conserved Domains (1) summary
    cd07699
    Location:40132
    IgC_L; Immunoglobulin Constant domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    22887816..22896111
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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