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ERBB4 erb-b2 receptor tyrosine kinase 4 [ Callithrix jacchus (white-tufted-ear marmoset) ]

Gene ID: 100402965, updated on 11-Apr-2024

Summary

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Gene symbol
ERBB4
Gene description
erb-b2 receptor tyrosine kinase 4
See related
Ensembl:ENSCJAG00000011307
Gene type
protein coding
RefSeq status
MODEL
Organism
Callithrix jacchus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2023_03 current mCalJa1.2.pat.X (GCF_011100555.1) 6 NC_071447.1 (129512274..130732195, complement)
105 previous assembly Callithrix_jacchus_cj1700_1.1 (GCF_009663435.1) 6 NC_048388.1 (130721612..131942197, complement)

Chromosome 6 - NC_071447.1Genomic Context describing neighboring genes Neighboring gene LanC like glutathione S-transferase 1 Neighboring gene carbamoyl-phosphate synthase 1 Neighboring gene PC-esterase domain-containing protein 1B-like Neighboring gene IKAROS family zinc finger 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. De novo assembly of the common marmoset transcriptome from NextGen mRNA sequences. Maudhoo MD, et al. Gigascience, 2014. PMID 25243066, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables epidermal growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in basal plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
receptor tyrosine-protein kinase erbB-4
Names
v-erb-a erythroblastic leukemia viral oncogene homolog 4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_011100555.1-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mCalJa1.2.pat.X

Genomic

  1. NC_071447.1 Reference mCalJa1.2.pat.X

    Range
    129512274..130732195 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_035306588.2 → XP_035162479.1  receptor tyrosine-protein kinase erbB-4 isoform X5

    UniProtKB/TrEMBL
    F6UHY4
    Conserved Domains (5) summary
    cd05110
    Location:700 → 1002
    PTKc_HER4; Catalytic domain of the Protein Tyrosine Kinase, HER4
    cd12092
    Location:632 → 675
    TM_ErbB4; Transmembrane domain of ErbB4, a Protein Tyrosine Kinase
    pfam00757
    Location:186 → 332
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:55 → 167
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:502 → 634
    GF_recep_IV; Growth factor receptor domain IV

  2. XM_035306587.2 → XP_035162478.1  receptor tyrosine-protein kinase erbB-4 isoform X4

    UniProtKB/TrEMBL
    U3C7Y1
    Conserved Domains (5) summary
    cd05110
    Location:685 → 987
    PTKc_HER4; Catalytic domain of the Protein Tyrosine Kinase, HER4
    cd12092
    Location:617 → 660
    TM_ErbB4; Transmembrane domain of ErbB4, a Protein Tyrosine Kinase
    pfam00757
    Location:186 → 332
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:55 → 167
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:502 → 624
    GF_recep_IV; Growth factor receptor domain IV

  3. XM_035306586.2 → XP_035162477.1  receptor tyrosine-protein kinase erbB-4 isoform X3

    UniProtKB/TrEMBL
    U3C7Y1
    Conserved Domains (5) summary
    cd05110
    Location:710 → 1012
    PTKc_HER4; Catalytic domain of the Protein Tyrosine Kinase, HER4
    cd12092
    Location:642 → 685
    TM_ErbB4; Transmembrane domain of ErbB4, a Protein Tyrosine Kinase
    pfam00757
    Location:186 → 332
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:55 → 167
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:502 → 634
    GF_recep_IV; Growth factor receptor domain IV

  4. XM_008999419.4 → XP_008997667.1  receptor tyrosine-protein kinase erbB-4 isoform X1

    UniProtKB/TrEMBL
    F7HB76, U3C7Y1
    Related
    ENSCJAP00000020916.2
    Conserved Domains (8) summary
    cd05110
    Location:710 → 1012
    PTKc_HER4; Catalytic domain of the Protein Tyrosine Kinase, HER4
    cd12092
    Location:642 → 685
    TM_ErbB4; Transmembrane domain of ErbB4, a Protein Tyrosine Kinase
    smart00261
    Location:549 → 596
    FU; Furin-like repeats
    cd00064
    Location:229 → 274
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:186 → 332
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:55 → 167
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:718 → 974
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14843
    Location:502 → 634
    GF_recep_IV; Growth factor receptor domain IV

  5. XM_035306585.2 → XP_035162476.1  receptor tyrosine-protein kinase erbB-4 isoform X2

    UniProtKB/TrEMBL
    U3C7Y1
    Conserved Domains (5) summary
    cd05110
    Location:700 → 1002
    PTKc_HER4; Catalytic domain of the Protein Tyrosine Kinase, HER4
    cd12092
    Location:632 → 675
    TM_ErbB4; Transmembrane domain of ErbB4, a Protein Tyrosine Kinase
    pfam00757
    Location:186 → 332
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:55 → 167
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:502 → 634
    GF_recep_IV; Growth factor receptor domain IV

  6. XM_054257908.1 → XP_054113883.1  receptor tyrosine-protein kinase erbB-4 isoform X6

Nucleotide Protein
Heading Accession and Version

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