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Elp3 elongator acetyltransferase complex subunit 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100362548, updated on 2-Oct-2018

Summary

Official Symbol
Elp3provided by RGD
Official Full Name
elongator acetyltransferase complex subunit 3provided by RGD
Primary source
RGD:2324506
See related
Ensembl:ENSRNOG00000014291
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression
Biased expression in Brain (RPKM 278.7), Heart (RPKM 241.4) and 9 other tissues See more
Orthologs

Genomic context

See Elp3 in Genome Data Viewer
Location:
15p11
Exon count:
15
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (48942866..49005074, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 15 NC_005114.3 (52682548..52744186, complement)

Chromosome 15 - NC_005114.4Genomic Context describing neighboring genes Neighboring gene zinc finger protein 395 Neighboring gene prepronociceptin Neighboring gene annexin 2 pseudogene1 Neighboring gene ribosomal protein S17-like Neighboring gene nuclear GTPase, germinal center associated

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
RNA polymerase II complex binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to RNA polymerase II complex binding ISO
Inferred from Sequence Orthology
more info
 
acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
histone acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphorylase kinase regulator activity IEA
Inferred from Electronic Annotation
more info
 
phosphorylase kinase regulator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
central nervous system development IEA
Inferred from Electronic Annotation
more info
 
central nervous system development ISO
Inferred from Sequence Orthology
more info
 
histone acetylation IEA
Inferred from Electronic Annotation
more info
 
neuron migration IEA
Inferred from Electronic Annotation
more info
 
neuron migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Elongator holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Elongator holoenzyme complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription elongation factor complex IEA
Inferred from Electronic Annotation
more info
 
transcription elongation factor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
elongator complex protein 3
Names
elongation protein 3 homolog
rCG52086-like

NCBI Reference Sequences (RefSeq)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005114.4 Reference Rnor_6.0 Primary Assembly

    Range
    48942866..49005074 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003751505.4XP_003751553.1  elongator complex protein 3 isoform X1

    See identical proteins and their annotated locations for XP_003751553.1

    Conserved Domains (4) summary
    cd01335
    Location:115359
    Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...
    TIGR01211
    Location:56565
    ELP3; radical SAM enzyme/protein acetyltransferase, ELP3 family
    pfam00583
    Location:462555
    Acetyltransf_1; Acetyltransferase (GNAT) family
    pfam16199
    Location:333411
    Radical_SAM_C; Radical_SAM C-terminal domain
  2. XM_002728290.5XP_002728336.1  elongator complex protein 3 isoform X2

    See identical proteins and their annotated locations for XP_002728336.1

    UniProtKB/TrEMBL
    D4ACM1
    Related
    ENSRNOP00000019262.6, ENSRNOT00000019262.7
    Conserved Domains (4) summary
    cd01335
    Location:96340
    Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...
    TIGR01211
    Location:37546
    ELP3; radical SAM enzyme/protein acetyltransferase, ELP3 family
    pfam00583
    Location:443536
    Acetyltransf_1; Acetyltransferase (GNAT) family
    pfam16199
    Location:314392
    Radical_SAM_C; Radical_SAM C-terminal domain

Alternate Rn_Celera

Genomic

  1. AC_000083.1 Alternate Rn_Celera

    Range
    39428188..39489987 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003752820.4XP_003752868.1  elongator complex protein 3 isoform X1

    See identical proteins and their annotated locations for XP_003752868.1

    Conserved Domains (4) summary
    cd01335
    Location:115359
    Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...
    TIGR01211
    Location:56565
    ELP3; radical SAM enzyme/protein acetyltransferase, ELP3 family
    pfam00583
    Location:462555
    Acetyltransf_1; Acetyltransferase (GNAT) family
    pfam16199
    Location:333411
    Radical_SAM_C; Radical_SAM C-terminal domain
  2. XM_003752819.4XP_003752867.1  elongator complex protein 3 isoform X2

    See identical proteins and their annotated locations for XP_003752867.1

    UniProtKB/TrEMBL
    D4ACM1
    Conserved Domains (4) summary
    cd01335
    Location:96340
    Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...
    TIGR01211
    Location:37546
    ELP3; radical SAM enzyme/protein acetyltransferase, ELP3 family
    pfam00583
    Location:443536
    Acetyltransf_1; Acetyltransferase (GNAT) family
    pfam16199
    Location:314392
    Radical_SAM_C; Radical_SAM C-terminal domain
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